Title:
PRODUCTION METHOD FOR T CELLS OR NK CELLS, MEDIUM FOR CULTURING T CELLS OR NK CELLS, METHOD FOR CULTURING T CELLS OR NK CELLS, METHOD FOR MAINTAINING UNDIFFERENTIATED STATE OF UNDIFFERENTIATED T CELLS, AND GROWTH-ACCELERATING AGENT FOR T CELLS OR NK CELLS
Document Type and Number:
WIPO Patent Application WO/2020/116606
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a production method for T cells or NK cells, medium for culturing T cells or NK cells, a method for culturing T cells or NK cells, a method for maintaining the undifferentiated state of undifferentiated T cells, and growth-accelerating agent for T cells or NK cells, which enable efficient growth of T cells or NK cells, and enable maintaining of a state (e.g., undifferentiation) of the cells. The present invention pertains to a production method that is for T cells or NK cells and that comprises culturing T cells or NK cells in a medium containing a bisbenzylisoquinoline alkaloid represented by formula (X-1) or formula (X-2) or a compound obtained by cleaving one ether bond thereof or a pharmaceutically acceptable salt thereof, and the like.
Inventors:
TAKAYANAGI SHINICHIRO (JP)
KUNISATO ATSUSHI (JP)
CHUGANJI SAYAKA (JP)
FUKUMOTO KEN (JP)
NAKAZONO KAZUKI (JP)
KANEKO SHIN (JP)
KAWAI YOHEI (JP)
KUNISATO ATSUSHI (JP)
CHUGANJI SAYAKA (JP)
FUKUMOTO KEN (JP)
NAKAZONO KAZUKI (JP)
KANEKO SHIN (JP)
KAWAI YOHEI (JP)
Application Number:
PCT/JP2019/047808
Publication Date:
June 11, 2020
Filing Date:
December 06, 2019
Export Citation:
Assignee:
KIRIN HOLDINGS KK (JP)
UNIV KYOTO (JP)
UNIV KYOTO (JP)
International Classes:
C12N5/10; C12N15/09
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EMINLI S ET AL., STEM CELLS, vol. 26, 2008, pages 2467 - 2474
FENG B ET AL., NAT. CELL BIOL., vol. 11, 2009, pages 197 - 203
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LYSSIOTIS CA ET AL., PROC NATL ACAD SCI USA., vol. 106, 2009, pages 8912 - 8917
KIM JB ET AL., NATURE, vol. 461, 2009, pages 649 - 643
ICHIDA JK ET AL., CELL STEM CELL, vol. 5, 2009, pages 491 - 503
HENG JC ET AL., CELL STEM CELL, vol. 6, 2010, pages 167 - 74
HAN J ET AL., NATURE, vol. 463, 2010, pages 1096 - 100
MALI P ET AL., STEM CELLS, vol. 28, 2010, pages 713 - 720
MAEKAWA M ET AL., NATURE, vol. 474, 2011, pages 225 - 9
CANCER RES., vol. 66, 2006, pages 10995 - 11004
MOL THER., vol. 17, 2009, pages 1453 - 1464
BLOOD, vol. 105, no. 4, 2005, pages 1431 - 1439
JOURNAL OF ELECTROPHORESIS, vol. 60, 2015, pages 7 - 10
LANCET, vol. 365, no. 9471, 2005, pages 1636 - 1641
GATTINONI ET AL., NAT. MED., vol. 15, no. 7, 2009, pages 808 - 813
XIE ET AL., EUR J MED CHEM, vol. 44, no. 8, 2009, pages 3293 - 8
TAN ET AL., INTERNATIONAL JORNAL OF MASS SPETROMETRY, vol. 386, 2015, pages 37 - 41
NAM ET AL., MOL ONCOL, vol. 6, no. 5, 2012, pages 484 - 93
See also references of EP 3892722A4
ONO MINORU: "Anti-tumor effects of cepharanthin", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, vol. 15, no. 2, 30 November 1987 (1987-11-30), JP, pages 249 - 255, XP009528814, ISSN: 0385-0684
NISHIMURA T ET AL., CELL STEM CELL, vol. 12, no. 1, 2013, pages 114 - 126
TAKAYAMA N ET AL., JOURNAL OF EXPERIMENTAL MEDICINE, vol. 207, no. 13, 2010, pages 2817 - 2830
PORTER ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 7, no. 303, 2015, pages 303ra139
NICHOLAS P. RESTIFO, BLOOD, vol. 124, no. 4, 2014, pages 476 - 477
LI Y ET AL., CELL STEM CELL, vol. 23, no. 2, 2018, pages 181 - 192
J. IMMUNOL., vol. 165, no. 1, 2000, pages 139 - 147
EXPERIMENTAL HEMATOL., vol. 29, no. 1, 2001, pages 104 - 113
FRONT. IMMUNOL., vol. 8, no. 458, 2017, pages 1 - 18
YING GU ET AL., BLOOD, vol. 120, no. 24, 2012, pages 4829 - 4839
J ALLERGY CLIN. IMMUNOL., vol. 135, no. 3, 2012, pages 626 - 635
NATURE REVIEWS IMMUNOLOGY, vol. 18, 2018, pages 363 - 373
HUANGFU D ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 1269 - 1275
ZHAO Y ET AL., CELL STEM CELL, vol. 3, 2008, pages 132 - 135
EMINLI S ET AL., STEM CELLS, vol. 26, 2008, pages 2467 - 2474
FENG B ET AL., NAT. CELL BIOL., vol. 11, 2009, pages 197 - 203
R. L. JUDSON ET AL., NAT. BIOTECHNOL., vol. 27, 2009, pages 459 - 461
LYSSIOTIS CA ET AL., PROC NATL ACAD SCI USA., vol. 106, 2009, pages 8912 - 8917
KIM JB ET AL., NATURE, vol. 461, 2009, pages 649 - 643
ICHIDA JK ET AL., CELL STEM CELL, vol. 5, 2009, pages 491 - 503
HENG JC ET AL., CELL STEM CELL, vol. 6, 2010, pages 167 - 74
HAN J ET AL., NATURE, vol. 463, 2010, pages 1096 - 100
MALI P ET AL., STEM CELLS, vol. 28, 2010, pages 713 - 720
MAEKAWA M ET AL., NATURE, vol. 474, 2011, pages 225 - 9
CANCER RES., vol. 66, 2006, pages 10995 - 11004
MOL THER., vol. 17, 2009, pages 1453 - 1464
BLOOD, vol. 105, no. 4, 2005, pages 1431 - 1439
JOURNAL OF ELECTROPHORESIS, vol. 60, 2015, pages 7 - 10
LANCET, vol. 365, no. 9471, 2005, pages 1636 - 1641
GATTINONI ET AL., NAT. MED., vol. 15, no. 7, 2009, pages 808 - 813
XIE ET AL., EUR J MED CHEM, vol. 44, no. 8, 2009, pages 3293 - 8
TAN ET AL., INTERNATIONAL JORNAL OF MASS SPETROMETRY, vol. 386, 2015, pages 37 - 41
NAM ET AL., MOL ONCOL, vol. 6, no. 5, 2012, pages 484 - 93
See also references of EP 3892722A4
Attorney, Agent or Firm:
Eikoh Patent Firm, P.C. (JP)
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