Title:
PROPHYLACTIC OR THERAPEUTIC DRUG FOR DROWSINESS CAUSED BY PAINKILLER
Document Type and Number:
WIPO Patent Application WO/2019/112007
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a prophylactic or therapeutic drug for drowsiness caused by a painkiller such as an opioid. The present invention relates to a prophylactic or therapeutic drug which is for drowsiness caused by the administration of a painkiller and contains an orexin-2 receptor agonist.
Inventors:
NAGASE HIROSHI (JP)
YANAGISAWA MASASHI (JP)
SAITOH TSUYOSHI (JP)
SHIMOYAMA MEGUMI (JP)
YANAGISAWA MASASHI (JP)
SAITOH TSUYOSHI (JP)
SHIMOYAMA MEGUMI (JP)
Application Number:
PCT/JP2018/044917
Publication Date:
June 13, 2019
Filing Date:
December 06, 2018
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
UNIV TEXAS (US)
THE JIKEI UNIV (JP)
UNIV TEXAS (US)
THE JIKEI UNIV (JP)
International Classes:
A61K45/06; A61K31/137; A61K31/165; A61K31/18; A61K31/19; A61K31/195; A61K31/197; A61K31/255; A61K31/381; A61K31/4166; A61K31/485; A61K31/55; A61K31/5513; A61K31/553; A61K45/00; A61P25/04; A61P25/26; A61P43/00
Domestic Patent References:
| WO2016199906A1 | 2016-12-15 | |||
| WO2016133160A1 | 2016-08-25 | |||
| WO2015088000A1 | 2015-06-18 |
Foreign References:
| JP2010533717A | 2010-10-28 | |||
| JP2014505034A | 2014-02-27 |
Other References:
AKANMU, M. A. ET AL.: "Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats", BRAIN RESEARCH, vol. 1048, 2005, pages 138 - 145, XP004935498
SAMSON, W. K. ET AL.: "Orexin receptor subtype activation and locomotor behaviour in the rat", ACTA PHYSIOLOGICA, vol. 198, 2010, pages 313 - 324, XP55615416
MIEDA, MICHIHIRO ET AL.: "Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non- REM and REM Sleep", THE JOURNAL OF NEUROSCIENCE, vol. 31, no. 17, 2011, pages 6518 - 6526
KATAOKA, TOMOMI: "Patient education in cancer pain management with opioids", THE JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 65, no. 1, 2007, pages 42 - 48
TOYAMA, SATOSHI ET AL.: "Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats", ANESTHESIOLOGY, vol. 128, May 2018 (2018-05-01), pages 992 - 1003, XP55615418
SAMSON, W. K. ET AL.: "Orexin receptor subtype activation and locomotor behaviour in the rat", ACTA PHYSIOLOGICA, vol. 198, 2010, pages 313 - 324, XP55615416
MIEDA, MICHIHIRO ET AL.: "Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non- REM and REM Sleep", THE JOURNAL OF NEUROSCIENCE, vol. 31, no. 17, 2011, pages 6518 - 6526
KATAOKA, TOMOMI: "Patient education in cancer pain management with opioids", THE JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 65, no. 1, 2007, pages 42 - 48
TOYAMA, SATOSHI ET AL.: "Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats", ANESTHESIOLOGY, vol. 128, May 2018 (2018-05-01), pages 992 - 1003, XP55615418
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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