Title:
PROTEIN DEGRADATION AGENT COMPOUND PREPARATION METHOD AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2021/129653
Kind Code:
A1
Abstract:
Provided are a protein degradation agent compound preparation method and application; specifically, provided are the compound represented by formula (I) and a pharmacologically acceptable salt thereof, and an application of said compound in the degradation of androgen receptor (AR).
Inventors:
LU HONGFU (CN)
XING WEIQIANG (CN)
QI BAOJIAN (CN)
PENG JIANBIAO (CN)
GUO HAIBING (CN)
XING WEIQIANG (CN)
QI BAOJIAN (CN)
PENG JIANBIAO (CN)
GUO HAIBING (CN)
Application Number:
PCT/CN2020/138572
Publication Date:
July 01, 2021
Filing Date:
December 23, 2020
Export Citation:
Assignee:
SHANGHAI JEMINCARE PHARMACEUTICALS CO LTD (CN)
JIANGXI JEMINCARE GROUP CO LTD (CN)
JIANGXI JEMINCARE GROUP CO LTD (CN)
International Classes:
C07D209/34; A61K31/404; A61K31/454; A61P35/00; C07D401/14; C07D403/12
Domestic Patent References:
| WO2018098280A1 | 2018-05-31 | |||
| WO2018098275A1 | 2018-05-31 |
Foreign References:
| CN110506039A | 2019-11-26 | |||
| CN201911342649A | 2019-12-23 | |||
| CN202010200682A | 2020-03-20 | |||
| CN202010496353A | 2020-06-03 | |||
| CN202011486334A | 2020-12-16 | |||
| CN110506039A | 2019-11-26 |
Other References:
ISHOEY METTE, CHORN SOMETH, SINGH NATESH, JAEGER MARTIN G., BRAND MATTHIAS, PAULK JOSHIAWA, BAUER SOPHIE, ERB MICHAEL A., PARAPATI: "Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders", ACS CHEMICAL BIOLOGY, vol. 13, no. 3, 22 January 2018 (2018-01-22), pages 553 - 560, XP055823826, ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00969
SHYAM PANGA, NAVEEN KUMAR PODILA, VEERESHAM CIDDI: "Design, Synthesis, Characterization, and in Vitro Evaluation of Isatin-Pomalidomide Hybrids for Cytotoxicity against Multiple Myeloma", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 55, no. 12, 19 October 2018 (2018-10-19), pages 2919 - 2928, XP055823829, ISSN: 0022-152X, DOI: 10.1002/jhet.3365
See also references of EP 4083020A4
SHYAM PANGA, NAVEEN KUMAR PODILA, VEERESHAM CIDDI: "Design, Synthesis, Characterization, and in Vitro Evaluation of Isatin-Pomalidomide Hybrids for Cytotoxicity against Multiple Myeloma", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 55, no. 12, 19 October 2018 (2018-10-19), pages 2919 - 2928, XP055823829, ISSN: 0022-152X, DOI: 10.1002/jhet.3365
See also references of EP 4083020A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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