Title:
PROTEIN FUSION CONSTRUCTS POSSESSING THROMBOLYTIC AND ANTICOAGULANT PROPERTIES
Document Type and Number:
WIPO Patent Application WO/2012/017310
Kind Code:
A3
Abstract:
The present invention discloses novel hybrid proteins that have both plasminogen activator and anti-thrombotic properties, including clot specific action, that renders these as highly advantageous for the treatment of circulatory disorders involving fibrin clot formation due to underlying tissue damage in the blood vesels leading to myocardial infarction, strokes etc. Also disclosed are new proteins, and methods of obtaining the same, that help to dissolve blood clots by activating plasminogen in a plasmin or thrombin dependent manner and also inhibit both the activity and generation of thrombin through the intrinsic pathway of blood coagulation.
More Like This:
| WO/2019/037899 | [6R]-MTHF MULTIPLE BOLUS ADMINISTRATION IN 5-FLUOROURACIL BASED CHEMOTHERAPY |
| WO/2013/053641 | ALLERGENS FROM INSECTS |
| WO/2010/100878 | VANGL1 PEPTIDES AND VACCINES INCLUDING THE SAME |
Inventors:
MAHESHWARI NEERAJ (IN)
SAHNI GIRISH (IN)
SAHNI GIRISH (IN)
Application Number:
PCT/IB2011/001825
Publication Date:
July 19, 2012
Filing Date:
August 05, 2011
Export Citation:
Assignee:
COUNCIL SCIENT IND RES (IN)
MAHESHWARI NEERAJ (IN)
SAHNI GIRISH (IN)
MAHESHWARI NEERAJ (IN)
SAHNI GIRISH (IN)
International Classes:
A61K39/00; A61K48/00; C12P21/08
Foreign References:
| US20080019985A1 | 2008-01-24 | |||
| US20100034804A1 | 2010-02-11 | |||
| US20030092627A1 | 2003-05-15 | |||
| US20080171852A9 | 2008-07-17 |
Other References:
NOVOKHATNY ET AL.: "Domain structure and domain-domain interactions of recombinant tissue plasminogen activator.", J. BIOL. CHEM., vol. 266, no. 20, 1991, pages 12994 - 13002
HAYASHI ET AL.: "Further localization of binding sites for thrombin and protein C in human thrombomodulin.", J. BIOL. CHEM., vol. 265, no. 33, 1990, pages 20156 - 20159
HAYASHI ET AL.: "Further localization of binding sites for thrombin and protein C in human thrombomodulin.", J. BIOL. CHEM., vol. 265, no. 33, 1990, pages 20156 - 20159
Attorney, Agent or Firm:
DHAWAN, Ramesh, Chander (Plot No. B-28 Sector 32,Institutional Area, Gurgaon 1, IN)
Download PDF:
Previous Patent: WIRELESS HANDSET HAVING COMBINED MULTIPLE DISPLAYS
Next Patent: WELDED STRUCTURE AND WELDING METHOD
Next Patent: WELDED STRUCTURE AND WELDING METHOD