Title:
PSEUDO-TYPE RETROVIRUS VECTOR CONTAINING MEMBRANE PROTEIN HAVING HEMAGGLUTININ ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2001/092508
Kind Code:
A1
Abstract:
A retrovirus vector containing a membrane protein having a hemagglutinin activity. By using the membrane protein having a hemagglutinin activity, the retrovirus vector of the pseudo-type is constructed. This virus vector shows a high gene transfer efficiency into host cells. It is clarified that genes can be transferred thereby at a high efficiency into cells into which genes can be hardly transferred by the conventional techniques, for example, blood cells and hematopoietic cells involving hematopoietic stem cells and mucous cells involving mucosa epithelial cells. This virus vector is highly useful as a vector for gene therapy.
Inventors:
YONEMITSU YOSHIKAZU (JP)
NAKAJIMA TOSHIHIRO (JP)
NAKAMARU KENJI (JP)
KOBAYASHI MASANORI (JP)
HASEGAWA MAMORU (JP)
UEDA YASUJI (JP)
IIDA AKIHIRO (JP)
SAKAKIBARA HIROYUKI (JP)
NAKAJIMA TOSHIHIRO (JP)
NAKAMARU KENJI (JP)
KOBAYASHI MASANORI (JP)
HASEGAWA MAMORU (JP)
UEDA YASUJI (JP)
IIDA AKIHIRO (JP)
SAKAKIBARA HIROYUKI (JP)
Application Number:
PCT/JP2001/004659
Publication Date:
December 06, 2001
Filing Date:
June 01, 2001
Export Citation:
Assignee:
DNAVEC RESEARCH INC (JP)
YONEMITSU YOSHIKAZU (JP)
NAKAJIMA TOSHIHIRO (JP)
NAKAMARU KENJI (JP)
KOBAYASHI MASANORI (JP)
HASEGAWA MAMORU (JP)
UEDA YASUJI (JP)
IIDA AKIHIRO (JP)
SAKAKIBARA HIROYUKI (JP)
YONEMITSU YOSHIKAZU (JP)
NAKAJIMA TOSHIHIRO (JP)
NAKAMARU KENJI (JP)
KOBAYASHI MASANORI (JP)
HASEGAWA MAMORU (JP)
UEDA YASUJI (JP)
IIDA AKIHIRO (JP)
SAKAKIBARA HIROYUKI (JP)
International Classes:
A61K35/76; C12N5/074; C12N5/10; C12N15/86; C12N15/867; A61K48/00; (IPC1-7): C12N15/09; C12N5/10; A61K35/76; A61K48/00
Domestic Patent References:
| WO1999013905A1 | 1999-03-25 |
Other References:
T. HATZIIOANNOU ET AL.: "Incorporation of fowl plague virus hemagglutinin into murine leukemia virus particles and analysis of the infectivity of the pseudotyped retroviruses", J. VIROL., vol. 72, no. 6, 1998, pages 5313 - 5317, XP002945649
J. DONG ET AL.: "A chimeric avian retrovirus containing the influenza virus hemaglutinin gene has an expanded host range", J. VIROL., vol. 66, no. 12, 1992, pages 7374 - 7382, XP002945650
T. MORRISON ET AL.: "Complementation between avirulent newcastle disease virus and a fusion protein gene expressed from a retrovirus vector: requirements for membrane fusion", J. VIROL., vol. 65, no. 2, 1991, pages 813 - 822, XP002945651
Y.P. AGRAWAL ET AL.: "Cell-cycle kinetics and VSV-G pseudotyped retrovirus-mediated gene transfer in blood-derived CD34 cells", EXP. HEMATOLOGY, vol. 24, 1996, pages 738 - 747, XP002945652
J. DONG ET AL.: "A chimeric avian retrovirus containing the influenza virus hemaglutinin gene has an expanded host range", J. VIROL., vol. 66, no. 12, 1992, pages 7374 - 7382, XP002945650
T. MORRISON ET AL.: "Complementation between avirulent newcastle disease virus and a fusion protein gene expressed from a retrovirus vector: requirements for membrane fusion", J. VIROL., vol. 65, no. 2, 1991, pages 813 - 822, XP002945651
Y.P. AGRAWAL ET AL.: "Cell-cycle kinetics and VSV-G pseudotyped retrovirus-mediated gene transfer in blood-derived CD34 cells", EXP. HEMATOLOGY, vol. 24, 1996, pages 738 - 747, XP002945652
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-shi, Ibaraki, JP)
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