PTERIDINONE DERIVATIVE AND USE THEREOF - UNIV EAST CHINA SCIENCE & TECH

Title:

PTERIDINONE DERIVATIVE AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/046114

Kind Code:

A1

Abstract:

Disclosed in the present invention is a compound as represented by formula I or a pharmaceutically acceptable salt thereof. Such compounds exhibit an excellent effect of targeted inhibition of non-canonical mutations of EGFR and have a good anti-tumor activity. Further disclosed in the present invention are the use of the compound in the preparation of a drug for preventing or/and treating EGFR-mutation-mediated diseases, such as cancer, and a pharmaceutical composition containing the compound.

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Inventors:

LI HONGLIN (CN)
ZHAO ZHENJIANG (CN)
CHEN ZHUO (CN)
XU YUFANG (CN)
WANG CAOLIN (CN)
SHA WENJIE (CN)
QIAN XUHONG (CN)

Application Number:

PCT/CN2022/121058

Publication Date:

March 30, 2023

Filing Date:

September 23, 2022

Export Citation:

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Assignee:

UNIV EAST CHINA SCIENCE & TECH (CN)

International Classes:

C07D475/00; A61K31/519; A61P35/00; A61P35/02

Domestic Patent References:

WO2016192609A1	2016-12-08
WO2013170671A1	2013-11-21
WO2006002367A1	2006-01-05
WO2020142612A1	2020-07-09
WO2022042755A1	2022-03-03

Foreign References:

CN108721298A	2018-11-02
CN1373763A	2002-10-09

Attorney, Agent or Firm:

XU&PARTNERS, LLC. (CN)

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