Title:
PULMONARY HYPERTENSION TREATING AGENT
Document Type and Number:
WIPO Patent Application WO/2015/080180
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of providing a compound that is useful for preventing or treating diseases associated with malfunctioning of PGI2 receptors, in particular, pulmonary hypertension. [Solution] A positive allosteric regulator of a PGI2 receptor which comprises a compound represented by formula (1) or a pharmaceutically acceptable salt, hydrate or solvate thereof.
(1)
(In the formula, R1 is a branched chain or cyclic alkyl or alkenyl having 3 to 10 carbon atoms which may be substituted, R2 is a hydrogen atom or an alkyl having 1 to 6 carbon atoms which may be substituted, R3 is 1 to 4 substituents which are the same or different independently selected from the group consisting of a hydrogen atom, a halogen atom, an alkyl having 1 to 6 carbon atoms which may be substituted, and an alkoxy having 1 to 6 carbon atoms which may be substituted, and A is an aryl which may be substituted or a heteroaryl which may be substituted.)
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Inventors:
NAGANO TETSUO (JP)
OKABE TAKAYOSHI (JP)
KOJIMA HIROTATSU (JP)
SUZUKI AKIFUMI (JP)
HANAOKA KENJIRO (JP)
SHIMONISHI MANABU (JP)
EGASHIRA SHINICHIRO (JP)
NAKANO HIROFUMI (JP)
KUMAGAI KAZUO (JP)
MIYACHI HIROYUKI (JP)
MATSUNO KENJI (JP)
WAKI MINORU (JP)
OKABE TAKAYOSHI (JP)
KOJIMA HIROTATSU (JP)
SUZUKI AKIFUMI (JP)
HANAOKA KENJIRO (JP)
SHIMONISHI MANABU (JP)
EGASHIRA SHINICHIRO (JP)
NAKANO HIROFUMI (JP)
KUMAGAI KAZUO (JP)
MIYACHI HIROYUKI (JP)
MATSUNO KENJI (JP)
WAKI MINORU (JP)
Application Number:
PCT/JP2014/081314
Publication Date:
June 04, 2015
Filing Date:
November 27, 2014
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV OKAYAMA NAT UNIV CORP (JP)
UNIV OKAYAMA NAT UNIV CORP (JP)
International Classes:
A61K31/472; A61K31/343; A61K31/4174; A61K31/437; A61K31/5578; A61K31/5585; A61K45/00; A61P9/12; A61P43/00
Foreign References:
| US20100210836A1 | 2010-08-19 |
Other References:
DATABASE REGISTRY 25 September 2008 (2008-09-25), accession no. 052523- 18-8
DATABASE REGISTRY 3 March 2005 (2005-03-03), accession no. 41231-73-0
DATABASE REGISTRY 3 March 2005 (2005-03-03), accession no. 41231-72-9
DATABASE REGISTRY 3 March 2005 (2005-03-03), accession no. 41231-71-8
DATABASE REGISTRY 28 February 2005 (2005-02-28), accession no. 38860-86-9
DATABASE REGISTRY 31 January 2005 (2005-01-31), accession no. 23194- 09-8
AKIFUMI SUZUKI ET AL.: "Hai Koketsuatsusho Chiryoyaku Kaihatsu o Mezashita Tansaku Kenkyu", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 131 ST, no. 2, 5 March 2011 (2011-03-05), pages 78
DATABASE REGISTRY 3 March 2005 (2005-03-03), accession no. 41231-73-0
DATABASE REGISTRY 3 March 2005 (2005-03-03), accession no. 41231-72-9
DATABASE REGISTRY 3 March 2005 (2005-03-03), accession no. 41231-71-8
DATABASE REGISTRY 28 February 2005 (2005-02-28), accession no. 38860-86-9
DATABASE REGISTRY 31 January 2005 (2005-01-31), accession no. 23194- 09-8
AKIFUMI SUZUKI ET AL.: "Hai Koketsuatsusho Chiryoyaku Kaihatsu o Mezashita Tansaku Kenkyu", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 131 ST, no. 2, 5 March 2011 (2011-03-05), pages 78
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
Makoto Ono (JP)
Makoto Ono (JP)
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