PURIFIED AND ISOLATED PLATELET CALCIUM CHANNEL NUCLEIC ACIDS AND POLYPEPTIDES AND THERAPEUTIC AND SCREENING METHODS USING SAME

Title:

PURIFIED AND ISOLATED PLATELET CALCIUM CHANNEL NUCLEIC ACIDS AND POLYPEPTIDES AND THERAPEUTIC AND SCREENING METHODS USING SAME

Document Type and Number:

WIPO Patent Application WO2002063000

Kind Code:

A9

Abstract:

Isolated and purified platelet voltage dependent calcium channel (VDCC), alpha 1 subunit polypeptides, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to platelet VDCC alpha 1 subunit polypeptides have biological activity in calcium transport. Thus, therapeutic and diagnostic methods involving this activity are also disclosed.

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Inventors:

MALOUF NADIA (US)
NICHOLS TIMOTHY C (US)

Application Number:

PCT/US2001/050328

Publication Date:

April 24, 2003

Filing Date:

December 20, 2001

Export Citation:

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Assignee:

UNIV NORTH CAROLINA CHAPEL HILL (US)
MALOUF NADIA (US)
NICHOLS TIMOTHY C (US)

International Classes:

C07K14/705; C12N15/12; G01N33/68; A61K38/00; A61K48/00; (IPC1-7): C12N15/12; C07K14/705; C07K16/28; G01N33/53; C12Q1/68; G01N33/68; A61K38/17; A61K48/00; A61K31/70; C12N15/11; A61K39/395; A01K67/027

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