Title:
PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS
Document Type and Number:
WIPO Patent Application WO2004099154
Kind Code:
A3
Abstract:
Compounds of formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycle, heterocyclealkyl, heteroaryl, or heteroarylalkyl; R4 is formula (Ia), formula (Ib), formula (Ic), formula (Id), formula (Ie) or formula (If); or formula (II), or a pharmaceutically acceptable salt, amide, ester or prodrug thereof, wherein R14 is formula (III), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX), formula (X), formula (XI), or formula (XII); modulate PN3 in mammals and are useful in treating pain in mammals.
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Inventors:
ATKINSON ROBERT N (US)
DRIZEN IRENE (US)
GREGG ROBERT J (US)
GROSS MICHAEL F (US)
KORT MICHAEL E (US)
SHI LEI (US)
DRIZEN IRENE (US)
GREGG ROBERT J (US)
GROSS MICHAEL F (US)
KORT MICHAEL E (US)
SHI LEI (US)
Application Number:
PCT/US2004/013530
Publication Date:
April 14, 2005
Filing Date:
April 29, 2004
Export Citation:
Assignee:
ABBOTT LAB (US)
ATKINSON ROBERT N (US)
DRIZEN IRENE (US)
GREGG ROBERT J (US)
GROSS MICHAEL F (US)
KORT MICHAEL E (US)
SHI LEI (US)
ATKINSON ROBERT N (US)
DRIZEN IRENE (US)
GREGG ROBERT J (US)
GROSS MICHAEL F (US)
KORT MICHAEL E (US)
SHI LEI (US)
International Classes:
A61K31/416; A61K31/454; A61K31/496; A61K31/5377; A61K31/541; C07D231/14; C07D231/20; C07D231/22; C07D231/24; C07D401/04; C07D401/12; (IPC1-7): C07D231/14; A61K31/415; C07D231/20; C07D231/22; C07D231/24; C07D401/04; C07D401/12
Domestic Patent References:
| WO2001057024A1 | 2001-08-09 | |||
| WO1998028269A1 | 1998-07-02 | |||
| WO1998057937A2 | 1998-12-23 | |||
| WO1999032454A1 | 1999-07-01 | |||
| WO2000069849A1 | 2000-11-23 | |||
| WO2001019798A2 | 2001-03-22 | |||
| WO2003037274A2 | 2003-05-08 |
Foreign References:
| US6339099B1 | 2002-01-15 |
Other References:
PINTO, DONALD J. P. ET AL: "Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)- [1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa", JOURNAL OF MEDICINAL CHEMISTRY , 44(4), 566-578 CODEN: JMCMAR; ISSN: 0022-2623, 2001, XP002302828
MUTLIB, ABDUL E. ET AL: "P450-mediated metabolism of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)- [1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole- 5-carboxamide (DPC 423) and its analogs to aldoximes. Characterization of glutathione conjugates of postulated intermediates derived from aldoximes", CHEMICAL RESEARCH IN TOXICOLOGY , 15(1), 63-75 CODEN: CRTOEC; ISSN: 0893-228X, 2002, XP002302829
KORDIK, C. P. ET AL: "Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 11(17), 2287-2290 CODEN: BMCLE8; ISSN: 0960-894X, 2001, XP002302830
LAM, PATRICK Y. S. ET AL: "Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants", JOURNAL OF MEDICINAL CHEMISTRY , 46(21), 4405-4418 CODEN: JMCMAR; ISSN: 0022-2623, 9 October 2003 (2003-10-09), XP002302831
PRUITT, JAMES R. ET AL: "Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2'- (aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY , 46(25), 5298-5315 CODEN: JMCMAR; ISSN: 0022-2623, 4 December 2003 (2003-12-04), XP002302832
MUTLIB, ABDUL E. ET AL: "P450-mediated metabolism of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)- [1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole- 5-carboxamide (DPC 423) and its analogs to aldoximes. Characterization of glutathione conjugates of postulated intermediates derived from aldoximes", CHEMICAL RESEARCH IN TOXICOLOGY , 15(1), 63-75 CODEN: CRTOEC; ISSN: 0893-228X, 2002, XP002302829
KORDIK, C. P. ET AL: "Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 11(17), 2287-2290 CODEN: BMCLE8; ISSN: 0960-894X, 2001, XP002302830
LAM, PATRICK Y. S. ET AL: "Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants", JOURNAL OF MEDICINAL CHEMISTRY , 46(21), 4405-4418 CODEN: JMCMAR; ISSN: 0022-2623, 9 October 2003 (2003-10-09), XP002302831
PRUITT, JAMES R. ET AL: "Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2'- (aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY , 46(25), 5298-5315 CODEN: JMCMAR; ISSN: 0022-2623, 4 December 2003 (2003-12-04), XP002302832
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