Title:
PYRAZOLE DERIVATIVE, PHARMACEUTICAL COMPOSITION, AND USE
Document Type and Number:
WIPO Patent Application WO/2024/051727
Kind Code:
A1
Abstract:
The present invention relates to a pyrazole derivative, a pharmaceutical a composition, and a use. The pyrazole derivative has a structure as represented by formula (I). The pyrazole derivative has good activity inhibition selectivity with respect ot CDK2.
Inventors:
HU PU (CN)
LU JUQUAN (CN)
LU JUQUAN (CN)
Application Number:
PCT/CN2023/117196
Publication Date:
March 14, 2024
Filing Date:
September 06, 2023
Export Citation:
Assignee:
STARG WUHAN PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07D487/04; A61K31/415; A61K31/4162; A61P35/00; C07D403/12; C07D471/04
Domestic Patent References:
| WO2022174031A1 | 2022-08-18 | |||
| WO2022135365A1 | 2022-06-30 | |||
| WO2023160572A1 | 2023-08-31 | |||
| WO2023168686A1 | 2023-09-14 | |||
| WO2023116884A1 | 2023-06-29 | |||
| WO2023208143A1 | 2023-11-02 | |||
| WO2023274397A1 | 2023-01-05 |
Foreign References:
| CN115806551A | 2023-03-17 |
Other References:
YU, YANG ET AL.: "Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design", ACS MED. CHEM. LETT., vol. 14, 8 February 2023 (2023-02-08), pages 297 - 304, XP093088546, DOI: 10.1021/acsmedchemlett.2c00515
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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