PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES

WIPO Patent Application WO/2015/191506

A3

The present invention is directed to pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer's patients. More specifically, this invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study tau deposits in brain in vivo to allow diagnosis of Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology. The invention further relates to a method of measuring clinical efficacy of therapeutic agents for Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.

WALJI ABBAS M (US)
HOSTETLER ERIC (US)
GRESHOCK THOMAS (US)
LI JING (US)
MOORE KEITH P (US)
BENNACEF IDRISS (US)
MULHEARN JAMES (US)
SELNICK HAROLD (US)
WANG YAODE (CN)
YANG KUN (CN)
FU JIANMIN (CN)

PCT/US2015/034794

February 04, 2016

June 09, 2015

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MERCK SHARP & DOHME (US)
WALJI ABBAS M (US)
HOSTETLER ERIC (US)
GRESHOCK THOMAS (US)
LI JING (US)
MOORE KEITH P (US)
BENNACEF IDRISS (US)
MULHEARN JAMES (US)
SELNICK HAROLD (US)
WANG YAODE (CN)
YANG KUN (CN)
FU JIANMIN (CN)

C07D471/04

WO2014140592A1

2014-09-18

US20090203903A1	2009-08-13
US20130102587A1	2013-04-25
US5451566A	1995-09-19

DATABASE PUBCHEM [o] 13 February 2015 (2015-02-13), XP055371139, Database accession no. 90433905

MERCK SHARP & DOHME CORP. (Rahway, New Jersey, US)

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