Title:
RADIOACTIVE COMPOSITION AND PROCESS FOR PRODUCING RADIOACTIVE COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2005/092395
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a radioactive composition which contains, as an active ingredient, iomazenil labelled with radioactive iodine and has a makeup capable of inhibiting the iomazenil labelled with radioactive iodine from being decomposed by a radiation; and a process for producing the composition without fail. [MEANS FOR SOLVING PROBLEMS] Ascorbic acid is incorporated into a composition which contains, as an active ingredient, iomazenil labelled with radioactive iodine, whereby the compound can be inhibited from being decomposed by a radiation. In the step of purifying the composition, a hydrophobic organic solvent is used. Immediately after the solvent extraction step employing the organic solvent, the eluate is added to an aqueous solution containing ascorbic acid. Thus, the composition can be produced without fail.
Inventors:
YOSHIMURA HIROKATSU (JP)
ITO OSAMU (JP)
KURAMI MIKI (JP)
ITO OSAMU (JP)
KURAMI MIKI (JP)
Application Number:
PCT/JP2005/004086
Publication Date:
October 06, 2005
Filing Date:
March 09, 2005
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
YOSHIMURA HIROKATSU (JP)
ITO OSAMU (JP)
KURAMI MIKI (JP)
YOSHIMURA HIROKATSU (JP)
ITO OSAMU (JP)
KURAMI MIKI (JP)
International Classes:
A61K51/00; G21H5/02; (IPC1-7): A61K51/00; G21H5/02
Domestic Patent References:
| WO2003000271A2 | 2003-01-03 |
Foreign References:
| JPH0269479A | 1990-03-08 | |||
| US4880615A | 1989-11-14 |
Attorney, Agent or Firm:
Ide, Masatake (9F Gobancho Grand Bldg., 3-1, Gobanch, Chiyoda-ku Tokyo 76, JP)
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