Title:
RADIOACTIVELY LABELED SUBSTANCE
Document Type and Number:
WIPO Patent Application WO/2010/125647
Kind Code:
A1
Abstract:
Disclosed are: a radioactively labeled substance which can be accumulated in a target efficiently and is highly stable in vivo； and diagnosis and treatment using the radioactively labeled substance. Specifically disclosed are: a radioactively labeled substance which comprises a complex composed of a ligand and a radioactive nuclear species of a metal (e.g., technetium, rhenium) and of which accumulation in a target site is increased, wherein the ligand is bound to a compound capable of binding to a target molecule and can form a polycoordinated complex with the metal; use of the radioactively labeled substance for diagnosis or treatment; a ligand for use in the preparation of the radioactively labeled substance; a kit comprising a material comprising the ligand and a material comprising a radioactive nuclear species of a metal, wherein both the materials are packed in separate package units; and a method for increasing the accumulation of a radioactively labeled substance in a target site, which is characterized by using the aforementioned radioactively labeled substance.
Inventors:
ARANO YASUSHI (JP)
UEHARA TOMOYA (JP)
UEHARA TOMOYA (JP)
Application Number:
PCT/JP2009/058372
Publication Date:
November 04, 2010
Filing Date:
April 28, 2009
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
ARANO YASUSHI (JP)
UEHARA TOMOYA (JP)
ARANO YASUSHI (JP)
UEHARA TOMOYA (JP)
International Classes:
A61K51/00; A61P35/00
Foreign References:
| JPH10501531A | 1998-02-10 |
Other References:
TOMOYA UEHARA ET AL.: "Taka Koka ni yoru Hyoteki Bunshi eno Shuseki Kojo o Mezashita Aratana 99mTc Hyoshiki Yakuzai no Sekkei", JAPANESE JOURNAL OF NUCLEAR MEDICINE, vol. 45, no. 3, 30 September 2008 (2008-09-30), pages S189, XP008155227
TOMOYA UEHARA ET AL.: "Hyoteki Bunshi eno Shuseki Kojo o Mokuteki to suru Aratana 99mTc Hyoshiki Yakuzai no Sekkei", JAPANESE JOURNAL OF NUCLEAR MEDICINE, vol. 44, no. 3, 30 October 2007 (2007-10-30), pages S185, XP008155226
YO YOKOYAMA ET AL.: "99mTc Hyoshiki Kagobutsu no Hyoshiki Kagaku to sono Hinshitsu Kanri", JAPANESE JOURNAL OF RADIOLOGICAL TECHNOLOGY, vol. 38, no. 1, January 1982 (1982-01-01), pages 66 - 72, XP008154669
WUST F; CARLSON KE; KATZENELLENBOGEN JA; SPIES H; JOHANNSEN B: "Synthesis and binding affinities of new 17 alpha-substituted estradiol-rhenium ''n+1'' mixed-ligand and thioether-carbonyl complexes", STEROIDS, vol. 63, 1998, pages 665 - 71, XP004151182, DOI: doi:10.1016/S0039-128X(98)00079-8
JURISSON SS; LYDON JD: "Potential technetium small molecule radiopharmaceuticals", CHEM REV, vol. 99, 1999, pages 2205 - 18
MULDER A; HUSKENS J; REINHOUDT DN: "Multivalency in supramolecular chemistry and nanofabrication", ORG BIOMOL CHEM, vol. 2, 2004, pages 3409 - 24
ARANO Y: "Recent advances in 99mTc radiopharmaceuticals", J NUCL RADIOCHEM SCI, vol. 6, 2005, pages 177 - 181
HAUBNER R; WESTER HJ; REUNING U; SENEKOWITSCH-SCHMIDTKE R; DIEFENBACH B; KESSLER H; STOCKLIN G; SCHWAIGER M.: "Radiolabeled alpha (v) beta 3 integrin in antagonists: a new class of tracers for tumor targeting", J. NUCL. MED., vol. 40, 1999, pages 1061 - 71
See also references of EP 2425861A4
TOMOYA UEHARA ET AL.: "Hyoteki Bunshi eno Shuseki Kojo o Mokuteki to suru Aratana 99mTc Hyoshiki Yakuzai no Sekkei", JAPANESE JOURNAL OF NUCLEAR MEDICINE, vol. 44, no. 3, 30 October 2007 (2007-10-30), pages S185, XP008155226
YO YOKOYAMA ET AL.: "99mTc Hyoshiki Kagobutsu no Hyoshiki Kagaku to sono Hinshitsu Kanri", JAPANESE JOURNAL OF RADIOLOGICAL TECHNOLOGY, vol. 38, no. 1, January 1982 (1982-01-01), pages 66 - 72, XP008154669
WUST F; CARLSON KE; KATZENELLENBOGEN JA; SPIES H; JOHANNSEN B: "Synthesis and binding affinities of new 17 alpha-substituted estradiol-rhenium ''n+1'' mixed-ligand and thioether-carbonyl complexes", STEROIDS, vol. 63, 1998, pages 665 - 71, XP004151182, DOI: doi:10.1016/S0039-128X(98)00079-8
JURISSON SS; LYDON JD: "Potential technetium small molecule radiopharmaceuticals", CHEM REV, vol. 99, 1999, pages 2205 - 18
MULDER A; HUSKENS J; REINHOUDT DN: "Multivalency in supramolecular chemistry and nanofabrication", ORG BIOMOL CHEM, vol. 2, 2004, pages 3409 - 24
ARANO Y: "Recent advances in 99mTc radiopharmaceuticals", J NUCL RADIOCHEM SCI, vol. 6, 2005, pages 177 - 181
HAUBNER R; WESTER HJ; REUNING U; SENEKOWITSCH-SCHMIDTKE R; DIEFENBACH B; KESSLER H; STOCKLIN G; SCHWAIGER M.: "Radiolabeled alpha (v) beta 3 integrin in antagonists: a new class of tracers for tumor targeting", J. NUCL. MED., vol. 40, 1999, pages 1061 - 71
See also references of EP 2425861A4
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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