Title:
READ-THROUGH INDUCING AGENT AND PHARMACEUTICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/186365
Kind Code:
A1
Abstract:
The present invention relates to a novel read-through inducing agent, and also relates to a compound represented by general formula (I) (symbols in the formula are as described in the specification) or a pharmaceutically accepted salt thereof, and a pharmaceutical composition containing the compound as an effective component. Because the compound has the read-through activity, the present invention can provide a drug useful as an agent to prevent or treat nonsense-mediated genetic diseases such as muscular dystrophy, Duchenne muscular dystrophy, cystic fibrosis, mucopolysaccharidosis, ceroid lipofuscinosis, and Niemann-Pick disease.
Inventors:
TAKEDA SHIGEMITSU (JP)
SHIRAHASE HIROAKI (JP)
TAKASHIMA SHUNSUKE (JP)
KITAO TATSUYA (JP)
SHIRAHASE HIROAKI (JP)
TAKASHIMA SHUNSUKE (JP)
KITAO TATSUYA (JP)
Application Number:
PCT/JP2018/014162
Publication Date:
October 11, 2018
Filing Date:
April 02, 2018
Export Citation:
Assignee:
KYOTO PHARMA IND (JP)
International Classes:
C07D215/12; A61K31/352; A61K31/415; A61K31/4174; A61K31/4192; A61K31/4196; A61K31/42; A61K31/421; A61K31/426; A61K31/437; A61K31/4439; A61K31/47; A61K31/495; A61K31/4965; A61K31/498; A61K31/4985; A61K31/501; A61K31/505; A61K31/506; A61K31/517; A61K31/5377; A61P21/00; A61P43/00; C07D215/233; C07D231/12; C07D233/64; C07D239/74; C07D241/12; C07D241/42; C07D249/06; C07D249/08; C07D261/12; C07D263/32; C07D263/34; C07D263/57; C07D271/06; C07D271/10; C07D277/28; C07D295/135; C07D311/30; C07D401/04; C07D403/06; C07D413/04; C07D471/04
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Other References:
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CHIU, HAO-CHIEH ET AL.: "Development of novel antibacterial a gents against methicillin-resistant Staphylococcus aureus", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 15, 1 August 2012 (2012-08-01), pages 4653 - 4660, XP028428222
SUN, XICHENG ET AL.: "Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxa mide modification", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 6, 15 March 2012 (2012-03-15), pages 2338 - 2342, XP028402869, Retrieved from the Internet
PARRISH A. CYNTHIA ET AL.: "Novel ATP-Competitive Kinesin Spindle Protein Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, no. 20, 4 October 2007 (2007-10-04), pages 4939 - 4952, XP055558263, Retrieved from the Internet
TANAKA, RIEKO ET AL.: "Design and synthesis of piperidine far nesyltransferase inhibitors with reduced glucuronidation pot entail", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 3, 2007, pages 1363 - 1382, XP055558268
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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