REAGENT FOR BLOOD VESSEL IMAGING - UNIV GUNMA NAT UNIV CORP

Title:

REAGENT FOR BLOOD VESSEL IMAGING

Document Type and Number:

WIPO Patent Application WO/2022/138550

Kind Code:

A1

Abstract:

The present invention addresses the problem of developing a novel reagent for blood vessel imaging that is easy to produce, highly sensitive and highly accurate. The present invention provides a reagent for blood vessel imaging that contains a compound comprising an oligoarginine represented by formula and a phosphor or fluorophore group bound to the C-terminal or N-terminal side of the oligoarginine.

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Inventors:

YOSHIHARA TOSHITADA (JP)
YASUKAGAWA MAMI (JP)
SUMI SAKURA (JP)
TOBITA SEIJI (JP)

Application Number:

PCT/JP2021/046991

Publication Date:

June 30, 2022

Filing Date:

December 20, 2021

Export Citation:

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Assignee:

UNIV GUNMA NAT UNIV CORP (JP)

International Classes:

A61K49/00; C07F15/00; C07K7/06; C07K7/08; G01N21/64

Other References:

YOSHIHARA TOSHITADA; HIRAKAWA YOSUKE; HOSAKA MASAHIRO; NANGAKU MASAOMI; TOBITA SEIJI: "Oxygen imaging of living cells and tissues using luminescent molecular probes", JOURNAL OF PHOTOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 30, 20 January 2017 (2017-01-20), AMSTERDAM, NL, pages 71 - 95, XP029940267, ISSN: 1389-5567, DOI: 10.1016/j.jphotochemrev.2017.01.001
YASUKAGAWA MAMI; YAMADA KEIICH; TOBITA SEIJI; YOSHIHARA TOSHITADA: "Ratiometric oxygen probes with a cell-penetrating peptide for imaging oxygen levels in living cells", JOURNAL OF PHOTOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 383, 25 July 2019 (2019-07-25), AMSTERDAM, NL, XP085785139, ISSN: 1010-6030, DOI: 10.1016/j.jphotochem.2019.111983