Title:
REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/091213
Kind Code:
A3
Abstract:
The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
Inventors:
VAN DUZER JOHN H (US)
MAZITSCHEK RALPH (US)
OGIER WALTER (US)
BRADNER JAMES ELLIOTT (US)
HUANG GUOXIANG (US)
XIE DEJIAN (CN)
YU NAN (CN)
MAZITSCHEK RALPH (US)
OGIER WALTER (US)
BRADNER JAMES ELLIOTT (US)
HUANG GUOXIANG (US)
XIE DEJIAN (CN)
YU NAN (CN)
Application Number:
PCT/US2011/021982
Publication Date:
December 01, 2011
Filing Date:
January 21, 2011
Export Citation:
Assignee:
ACETYLON PHARMACEUTICALS (US)
VAN DUZER JOHN H (US)
MAZITSCHEK RALPH (US)
OGIER WALTER (US)
BRADNER JAMES ELLIOTT (US)
HUANG GUOXIANG (US)
XIE DEJIAN (CN)
YU NAN (CN)
VAN DUZER JOHN H (US)
MAZITSCHEK RALPH (US)
OGIER WALTER (US)
BRADNER JAMES ELLIOTT (US)
HUANG GUOXIANG (US)
XIE DEJIAN (CN)
YU NAN (CN)
International Classes:
C07D239/42; A61K31/505; A61P25/00; A61P35/00; C07C233/78
Foreign References:
| US20090023786A1 | 2009-01-22 | |||
| US20090312363A1 | 2009-12-17 | |||
| US20070149495A1 | 2007-06-28 | |||
| US20040266769A1 | 2004-12-30 |
Other References:
See also references of EP 2526093A4
Attorney, Agent or Firm:
HSI, Jeffrey, D. et al. (P.o. Box 55874Boston, MA, US)
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