Title:
SAIKOSAPONIN C AS COMPOSITION FOR TREATING OR PREVENTING AGING VASCULAR DISEASES INCLUDING ARTERIOSCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2023/171998
Kind Code:
A1
Abstract:
The present invention relates to Saikosaponin C as a modulator for vascular aging and arteriosclerosis resulting therefrom, and provides a composition comprising Saikosaponin C as an active ingredient for treating, preventing, or alleviating aging vascular diseases, diseases due to vascular aging, specifically, arteriosclerosis, or symptoms due to vascular aging. The composition of the present invention is expected to be of great use in the treatment, prevention, and alleviation of arteriosclerosis as a supplement, substitute, or combination of an existing arteriosclerosis treatment that lowers LDL-C.
Inventors:
KIM BYEONG MO (KR)
Application Number:
PCT/KR2023/003013
Publication Date:
September 14, 2023
Filing Date:
March 06, 2023
Export Citation:
Assignee:
AGINGTARGET INC (KR)
International Classes:
A61K31/7048; A23L33/125; A61P3/06; A61P9/10; A61P9/12
Foreign References:
| KR20070002446A | 2007-01-05 | |||
| KR20170014975A | 2017-02-08 | |||
| KR20110061883A | 2011-06-10 |
Other References:
LEE TAE HO; CHANG JIHOON; KIM BYEONG MO: "Saikosaponin C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 445, no. 3, 22 February 2014 (2014-02-22), Amsterdam NL , pages 615 - 621, XP028633189, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2014.02.046
SHYU, K.-G. TSAI, S.-C. WANG, B.-W. LIU, Y.-C. LEE, C.-C.: "Saikosaponin C induces endothelial cells growth, migration and capillary tube formation", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 76, no. 7, 31 December 2004 (2004-12-31), GB , pages 813 - 826, XP004669811, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2004.10.003
SHYU, K.-G. TSAI, S.-C. WANG, B.-W. LIU, Y.-C. LEE, C.-C.: "Saikosaponin C induces endothelial cells growth, migration and capillary tube formation", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 76, no. 7, 31 December 2004 (2004-12-31), GB , pages 813 - 826, XP004669811, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2004.10.003
Attorney, Agent or Firm:
ECM IP & LAW FIRM (KR)
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