Title:
SALICYLIC ACID PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2023/027168
Kind Code:
A1
Abstract:
According to the present method, salicylic acid is produced with high productivity by causing a 2-halogenated benzoic acid to react at 155-300°C in an aqueous solvent in the presence of a copper source and a ligand. Preferably, a refinement step A for putting the obtained salicylic acid in contact with a styrene-based synthetic adsorbent, and/or a refinement step B for putting said salicylic acid in contact with zeolite, is further comprised. Source materials (for example, acetylsalicylic acid) for various pharmaceuticals or intermediates thereof can be derived from the compound of the present invention.
Inventors:
TANIIKE HIROTSUGU (JP)
TSUJI SHUNSUKE (JP)
NAGAHAMA MASAKI (JP)
KOBA YURIE (JP)
TSUJI SHUNSUKE (JP)
NAGAHAMA MASAKI (JP)
KOBA YURIE (JP)
Application Number:
PCT/JP2022/032190
Publication Date:
March 02, 2023
Filing Date:
August 26, 2022
Export Citation:
Assignee:
API CORP (JP)
International Classes:
C07C51/367; C07B61/00; C07C51/47; C07C65/10
Foreign References:
| JP2010511043A | 2010-04-08 | |||
| JPS5553240A | 1980-04-18 | |||
| JP2001064230A | 2001-03-13 | |||
| JPS5815939A | 1983-01-29 | |||
| JP2010511043A | 2010-04-08 | |||
| JP2021139134A | 2021-09-16 |
Other References:
KE FANG, CHEN XIAOLE, LI ZHENGKAI, XIANG HAIFENG, ZHOU XIANGGE: "Microwave-assisted copper-catalyzed hydroxylation of aryl halides in water", RSC ADVANCES, vol. 3, no. 45, 1 January 2013 (2013-01-01), pages 22837, XP093038710, DOI: 10.1039/c3ra44613a
MAITE L. DOCAMPO PALACIOS, ROLANDO F. PELLÓN COMDOM: "Synthesis of Salicylic Acid Derivatives in Presence of Ultrasonic Irradiation Using Water as Solvent", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 33, no. 10, 6 January 2003 (2003-01-06), US , pages 1783 - 1787, XP055293946, ISSN: 0039-7911, DOI: 10.1081/SCC-120018940
SYNTHETIC COMMUNICATIONS, vol. 32, no. 13, 2002, pages 2055 - 2059
MAITE L. DOCAMPO PALACIOS, ROLANDO F. PELLÓN COMDOM: "Synthesis of Salicylic Acid Derivatives in Presence of Ultrasonic Irradiation Using Water as Solvent", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 33, no. 10, 6 January 2003 (2003-01-06), US , pages 1783 - 1787, XP055293946, ISSN: 0039-7911, DOI: 10.1081/SCC-120018940
SYNTHETIC COMMUNICATIONS, vol. 32, no. 13, 2002, pages 2055 - 2059
Attorney, Agent or Firm:
SHIGENO, Tsuyoshi et al. (JP)
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