Title:
SECRETED CAVEOLIN AS A MARKER FOR PROSTATE CANCER
Document Type and Number:
WIPO Patent Application WO2003063690
Kind Code:
A3
Abstract:
Prostate cancer cells secrete cav-1 and that secreted cav-1 can stimulate viability and clonal growth in prostate cancer cells that do not express cav-1. The concept of a secreted autocrine or paracrine factor that directly contributes to androgen resistance in prostate cancer is novel and represents an efficient mechanism for maximizing resistance to various pro-apoptotic stimuli that metastatic cells often encounter during the highly inefficient process of metastasis. The detection of secreted cav-1 in patient sera has significant potential for clinical utility. Since, unlike PSA, secreted cav-1 is linked to malignant characteristics of prostate cancer cells, serum cav-1 has a unique prognostic and diagnostic capacity. The levels of cav-1 protein within prostate cancer tissues were evaluated directly using immunohistochemistry and RT-PCR as well as serum cav-1 levels in men who undergo radical prostatectomy with lymph node dissection. This identified prostate cancer related cav-1as a bio-marker with unique clinical potential including independent value in predicting biochemical recurrence following radical prostatectomy and prognostic significance. Cav-1 can also provide clinically useful prognostic information prior to surgery (biopsy and serum cav-1), is useful as a prognostic bio-marker, and also for the ability to predict the recurrence of prostate cancer.
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Inventors:
THOMPSON TIMOTHY C (US)
Application Number:
PCT/US2003/002754
Publication Date:
August 18, 2005
Filing Date:
January 31, 2003
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE (US)
THOMPSON TIMOTHY C (US)
THOMPSON TIMOTHY C (US)
International Classes:
G01N33/574; (IPC1-7): C12Q1/00; C07K16/00; C07K17/00; G01N33/53
Other References:
SCARDINO ET AL.: "Early detection of prostate cancer.", HUMAN PATHOLOGY., vol. 23, no. 3, March 1992 (1992-03-01), pages 211 - 222, XP002988810
YANG ET AL.: "Caveolin-1 expression in clinically COnfined human prostate cancer: A novel prognostic marker.", CANCER RESEARCH., vol. 59, 15 November 1999 (1999-11-15), pages 5719 - 5723, XP002988811
YANG ET AL.: "Caveolin-1 expression in clinically COnfined human prostate cancer: A novel prognostic marker.", CANCER RESEARCH., vol. 59, 15 November 1999 (1999-11-15), pages 5719 - 5723, XP002988811
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