Title:
SEQUENCES FOR TARGETING METASTATIC CELLS
Document Type and Number:
WIPO Patent Application WO1999022773
Kind Code:
A3
Abstract:
The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metastatic prostate cancer, may be treated by therapies which suppress expression of the caveolin gene. The present invention relates to biological technologies designed to block the activity of caveolin or the function of caveolae, including vector delivery of antisense caveolin sequences, the use of anti-caveolin antibodies, the use of promoters, and other approaches targeting the expression of caveolin.
Inventors:
THOMPSON TIMOTHY C
Application Number:
PCT/US1998/023542
Publication Date:
October 14, 1999
Filing Date:
November 05, 1998
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE (US)
International Classes:
C07K14/705; C12N15/113; A61K38/00; A61K48/00; (IPC1-7): C12N15/12; C12N15/11; C07K14/705; C12N15/85; A61K31/70; C07K16/28; G01N33/68
Domestic Patent References:
| WO1997018454A2 | 1997-05-22 | |||
| WO1994004196A1 | 1994-03-03 | |||
| WO1997009055A1 | 1997-03-13 |
Other References:
YANG, G. ET AL.: "Association of caveolin protein with prostate cancer progression.", JOURNAL OF UROLOGY, VOL. 157, NO. 4 SUPPL., PP. 446, ABSTRACT 1742, April 1997 (1997-04-01), XP002098898
BIST A ET AL: "Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1997 SEP 30) 94 (20) 10693-8., XP002111901
TULCHINSKY E ET AL: "Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1992 OCT 1) 89 (19) 9146-50, XP002111902
FIELDING C J ET AL: "Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1997 APR 15) 94 (8) 3753-8., XP002098899
SARGIACOMO, M. ET AL.: "Oligomeric structure of caveolin: implications for caveolae membrane organization", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 92, September 1995 (1995-09-01), pages 9407 - 9411, XP002098900
LI, S. ET AL.: "Src tyrosine kinases, Galpha subunits, and H-ras share a common membrane-anchored scaffolding protein, caveolin.", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 271, 15 November 1996 (1996-11-15), pages 29182 - 29190, XP002098901
NASU Y ET AL: "Suppression of caveolin expression induces androgen sensitivity in metastatic androgen -insensitive mouse prostate cancer cells.", NATURE MEDICINE, (1998 SEP) 4 (9) 1062-4., XP002098902
BIST A ET AL: "Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1997 SEP 30) 94 (20) 10693-8., XP002111901
TULCHINSKY E ET AL: "Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1992 OCT 1) 89 (19) 9146-50, XP002111902
FIELDING C J ET AL: "Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1997 APR 15) 94 (8) 3753-8., XP002098899
SARGIACOMO, M. ET AL.: "Oligomeric structure of caveolin: implications for caveolae membrane organization", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 92, September 1995 (1995-09-01), pages 9407 - 9411, XP002098900
LI, S. ET AL.: "Src tyrosine kinases, Galpha subunits, and H-ras share a common membrane-anchored scaffolding protein, caveolin.", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 271, 15 November 1996 (1996-11-15), pages 29182 - 29190, XP002098901
NASU Y ET AL: "Suppression of caveolin expression induces androgen sensitivity in metastatic androgen -insensitive mouse prostate cancer cells.", NATURE MEDICINE, (1998 SEP) 4 (9) 1062-4., XP002098902
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