Title:
SMALL MOLECULE INTERVENTION IN HIV-1 REPLICATION
Document Type and Number:
WIPO Patent Application WO1999025327
Kind Code:
A3
Abstract:
The instant invention is a series of small molecules which are inhibitors of HIV-1 Tat-TAR interaction. The compounds are useful in the treatment of HIV-1 infections.
Inventors:
CZARNIK ANTHONY WILLIAM (US)
MACK DAVID PHILLIP (US)
MEI HOUNG-YAU (US)
MORELAND DAVID WINSLOW (US)
MACK DAVID PHILLIP (US)
MEI HOUNG-YAU (US)
MORELAND DAVID WINSLOW (US)
Application Number:
PCT/US1998/019358
Publication Date:
September 23, 1999
Filing Date:
September 16, 1998
Export Citation:
Assignee:
WARNER LAMBERT CO (US)
CZARNIK ANTHONY WILLIAM (US)
MACK DAVID PHILLIP (US)
MEI HOUNG YAU (US)
MORELAND DAVID WINSLOW (US)
CZARNIK ANTHONY WILLIAM (US)
MACK DAVID PHILLIP (US)
MEI HOUNG YAU (US)
MORELAND DAVID WINSLOW (US)
International Classes:
A61K31/00; (IPC1-7): A61K31/495; A61K31/505; C07D241/38
Domestic Patent References:
| WO1996040759A1 | 1996-12-19 | |||
| WO1997027179A2 | 1997-07-31 | |||
| WO1996017832A1 | 1996-06-13 |
Foreign References:
| EP0657166A1 | 1995-06-14 | |||
| EP0708093A1 | 1996-04-24 |
Other References:
H.-Y. MEI ET AL.: "INHIBITION OF AN HIV-1 TAT-DERIVED PEPTIDE BINDING TO TAR RNA BY AMINOGLYCOSIDE ANTIBIOTICS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 22, 1995, pages 2755 - 2760, XP004135228
H.-Y- MEI ET AL.: "Discovery of Selective, Small-Molecule Inhibitors of RNA Complexes - I. The Tat Protein/TAR RNA Complexes Required for HIV-1 Transcription", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, no. 6, 1997, pages 1173 - 1184, XP002096444
H.-Y.MEI ET AL.: "Inhibitors of Protein-RNA Complexation That Target the RNA: Specific Recognition of Human Immunodeficiency Virus Type 1 TAR RNA by Small Organic Molecules", BIOCHEMISTRY, vol. 37, no. 40, 17 September 1998 (1998-09-17), pages 13204 - 14212, XP002096445
H.-Y- MEI ET AL.: "Discovery of Selective, Small-Molecule Inhibitors of RNA Complexes - I. The Tat Protein/TAR RNA Complexes Required for HIV-1 Transcription", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, no. 6, 1997, pages 1173 - 1184, XP002096444
H.-Y.MEI ET AL.: "Inhibitors of Protein-RNA Complexation That Target the RNA: Specific Recognition of Human Immunodeficiency Virus Type 1 TAR RNA by Small Organic Molecules", BIOCHEMISTRY, vol. 37, no. 40, 17 September 1998 (1998-09-17), pages 13204 - 14212, XP002096445
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