Title:
SODIUM CHANNELS SCN1A AND SCN3A
Document Type and Number:
WIPO Patent Application WO/2001/096552
Kind Code:
A1
Abstract:
A human sodium channel SCN1A having the amino acid sequence represented by SEQ ID NO:2; a human gene encoding this protein molecule; and SCN1A cDNA having the base sequence represented by SEQ ID NO:1. Another human sodium channel SCN3A having the amino acid sequence represented by SEQ ID NO:4; a human gene encoding this protein molecule; and SCN3A cDNA. These substances largely contribute to the clarification of a physiological mechanism in which excitant cells participate, the specification of the causes of various human diseases, and the development of novel remedies.
Inventors:
KANAZAWA ICHIRO (JP)
GOTO JUN (JP)
JEONG SEON-YONG (JP)
GOTO JUN (JP)
JEONG SEON-YONG (JP)
Application Number:
PCT/JP2001/004956
Publication Date:
December 20, 2001
Filing Date:
June 12, 2001
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
KANAZAWA ICHIRO (JP)
GOTO JUN (JP)
JEONG SEON YONG (JP)
KANAZAWA ICHIRO (JP)
GOTO JUN (JP)
JEONG SEON YONG (JP)
International Classes:
C07K14/705; C12P21/08; (IPC1-7): C12N15/09; C07K14/47; C07K16/18; C12P21/08
Other References:
M.S. MALO ET AL.: "Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24", CYTOGENET CELL GENET, vol. 67, 1994, pages 178 - 186, XP002945944
MASAHARU N. ET AL.: "Existence of distinct sodium channel messenger RNAs in rat brain", NATURE, vol. 320, 1986, pages 188 - 192, XP002945945
CHIUNG-MEI LU ET AL.: "Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit", J. MOL. NEUROSCI., vol. 10, 1998, pages 67 - 70, XP002945946
TOSHIAKI K. ET AL.: "Primary structure of rat brain sodium channel III deduced from the cDNA sequence", FEBS LETT., vol. 228, no. 1, 1988, pages 187 - 194, XP002945947
MASAHARU N. ET AL.: "Existence of distinct sodium channel messenger RNAs in rat brain", NATURE, vol. 320, 1986, pages 188 - 192, XP002945945
CHIUNG-MEI LU ET AL.: "Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit", J. MOL. NEUROSCI., vol. 10, 1998, pages 67 - 70, XP002945946
TOSHIAKI K. ET AL.: "Primary structure of rat brain sodium channel III deduced from the cDNA sequence", FEBS LETT., vol. 228, no. 1, 1988, pages 187 - 194, XP002945947
Attorney, Agent or Firm:
Nishizawa, Toshio (Udagawa-cho Shibuya-ku Tokyo, Udagawa-cho Shibuya-ku Tokyo, JP)
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