Title:
SOLUBLE INTERLEUKIN-20 RECEPTOR
Document Type and Number:
WIPO Patent Application WO2001046232
Kind Code:
A3
Abstract:
A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
Inventors:
FOSTER DONALD C
XU WENFENG
MADDEN KAREN L
KELLY JAMES D
SPRECHER CINDY A
BRANDT CAMERON S
RIXON MARK W
PRESNELL SCOTT R
FOX BRIAN A
XU WENFENG
MADDEN KAREN L
KELLY JAMES D
SPRECHER CINDY A
BRANDT CAMERON S
RIXON MARK W
PRESNELL SCOTT R
FOX BRIAN A
Application Number:
PCT/US2000/035307
Publication Date:
February 21, 2002
Filing Date:
December 22, 2000
Export Citation:
Assignee:
ZYMOGENETICS INC (US)
International Classes:
A61K38/00; A61P17/06; C12N15/09; A61P29/00; C07K14/54; C07K14/705; C07K16/00; (IPC1-7): C07K14/715; C12N15/62
Domestic Patent References:
| WO1999003982A1 | 1999-01-28 | |||
| WO2000039161A1 | 2000-07-06 | |||
| WO1999046281A2 | 1999-09-16 | |||
| WO1999046379A2 | 1999-09-16 | |||
| WO1999037772A1 | 1999-07-29 | |||
| WO1999061630A2 | 1999-12-02 |
Foreign References:
| US5945511A | 1999-08-31 |
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