Title:
SPHERICAL PARTICLES OF CLOPIDOGREL BISULFATE, PHARMACEUTICAL COMPOSITION INCLUDING SAME, AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2013/008981
Kind Code:
A1
Abstract:
The present invention relates to spherical particles of clopidogrel bisulfate having a 10% volume particle diameter (d0.1) of 30 μm or more and a 50% volume particle diameter (d0.5) in the range of 50 to 200 μm, and to a pharmaceutical composition including same. The spherical particles of the present invention not only significantly improve unfavorable properties in a conventional pharmaceutical preparation of clopidogrel bisulfate, i.e. defective compression and flow and a strong surface electrostatic force, but can also significantly reduce tableting impediments such as weight deviations and sticking during preparation by means of a direct powder compression technique, and the danger of crystalline conversion. Thus, the composition has improved physiochemical stability and, due to anti-clotting effects of the composition, can be effectively used as a therapeutic agent for arteriosclerosis, stroke, myocardial infarction, and atherosclerosis.
Inventors:
CHO EUI HWAN
SHIN HEE JONG
SONG WOO HEON
LEE SUN HWAN
YOON JONG BAE
PARK JONG SUNG
SHIN HEE JONG
SONG WOO HEON
LEE SUN HWAN
YOON JONG BAE
PARK JONG SUNG
Application Number:
PCT/KR2011/008071
Publication Date:
January 17, 2013
Filing Date:
October 27, 2011
Export Citation:
Assignee:
SAMJIN PHARM CO LTD (KR)
ASTECH CO LTD (KR)
CHO EUI HWAN
SHIN HEE JONG
SONG WOO HEON
LEE SUN HWAN
YOON JONG BAE
PARK JONG SUNG
ASTECH CO LTD (KR)
CHO EUI HWAN
SHIN HEE JONG
SONG WOO HEON
LEE SUN HWAN
YOON JONG BAE
PARK JONG SUNG
International Classes:
A61K9/16; A61K9/20; A61K31/4365; C07D495/04
Foreign References:
| KR20080098964A | 2008-11-12 | |||
| KR100809903B1 | 2008-03-06 | |||
| KR20090092106A | 2009-08-31 | |||
| KR20070009851A | 2007-01-19 | |||
| KR20070044323A | 2007-04-27 | |||
| US20070003628A1 | 2007-01-04 | |||
| US20100086590A1 | 2010-04-08 |
Attorney, Agent or Firm:
KIM, HYUN JIN (KR)
김현진 (KR)
김현진 (KR)
Download PDF:
Claims: