Title:
STEM CELL MATURATION FOR ALL TISSUE TYPES
Document Type and Number:
WIPO Patent Application WO2003062384
Kind Code:
A3
Abstract:
The present invention provides a composition and method for making a modified germ cell (MGC) comprising a primordial sex cell, (PSC) or nucleus thereof, combined with an enucleated ovum. The PSC is a spermatogonia or an oogonia from a donor animal or mammal. Similarly, the enucleated ovum is from the same species donor animal or mammal as the donor of the PSC. The present invention also provides a method of maturing the MGC in vitro using a specialized cell culture apparatus or bioreactor chamber. The present invention also provides for a method of screening the MGCs for receptor sites, to determine if they are sufficiently matured to be translocated into a host animal or mammal in vivo and/or tissue in vitro. The present invention also provides for a specialized cell culture chamber or bioreactor chamber to grow, expand, maintain, sustain and mature the MGCs, or other types of cells.
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Inventors:
SAYRE CHAUNCEY (US)
Application Number:
PCT/US2003/001570
Publication Date:
February 05, 2004
Filing Date:
January 16, 2003
Export Citation:
Assignee:
SAYRE CHAUNCEY (US)
International Classes:
C12N5/02; C12N5/074; C12N5/16; C12N15/873; A61K35/12; (IPC1-7): C12N15/00; C12M1/00; C12N5/00; C12N5/02; C12N5/06; C12N5/08; C12N5/10
Domestic Patent References:
| WO1999035906A1 | 1999-07-22 |
Foreign References:
| US6194635B1 | 2001-02-27 | |||
| US5888807A | 1999-03-30 | |||
| US5882918A | 1999-03-16 |
Other References:
See also references of EP 1468088A4
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