STREPTOGRAMINES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

Title:

STREPTOGRAMINES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

Document Type and Number:

WIPO Patent Application WO1999005165

Kind Code:

A8

Abstract:

The invention concerns derivatives of group A of streptogramines of general formula (I) in which R1 is a -NR'R'' radical in which R' is a hydrogen atom or a methyl radical, and R'' is a hydrogen atom, an alkyl, cycloalkyl, allyl, propynyl, benzyl radical or -OR''', R''' being a hydrogen atom, an alkyl, cycloalkyl, allyl, propynyl or benzyl radical, or -NR3R4, R3 and R4 representing a methyl radical, or forming together with the nitrogen atom to which they are bound a saturated or unsaturated heterocyclic compound with 5 or 6 chains, further capable of containing another heteroatom selected among nitrogen, oxygen or sulphur; R2 is a hydrogen atom or a methyl or ethyl radical, and the bond --- represents a single or double bond, and in which, except if it is specified, the alkyl radicals are linear or branched and contain 1 to 6 carbon atoms, the cycloalkyl radicals contain 3 to 4 carbon atoms, and the chain in position 16 means: when R'' is other than -OR''' or -NR3R4, the epimer R or the mixture of epimers R and S in which the epimer R constitutes the major part, and when R'' is -OR''' or -NR3R4, the epimers R and S and their mixtures and their salts. Said novel derivatives are particularly useful as antimicrobial agents, optionally combined with components of group B of streptogramines.

Inventors:

COMMERCON ALAIN (FR)
BOUCHARD HERVE (FR)
RIBEILL YVES (US)
BACQUE ERIC (FR)
RONAN BAPTISTE (FR)
BARRIERE JEAN-CLAUDE (FR)
PUCHAULT GERARD (FR)
TERRIER CORINNE (FR)

Application Number:

PCT/FR1998/001639

Publication Date:

April 29, 1999

Filing Date:

July 24, 1998

Export Citation:

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Assignee:

RHONE POULENC RORER SA (FR)
COMMERCON ALAIN (FR)
BOUCHARD HERVE (FR)
RIBEILL YVES (US)
BACQUE ERIC (FR)
RONAN BAPTISTE (FR)
BARRIERE JEAN CLAUDE (FR)
PUCHAULT GERARD (FR)
TERRIER CORINNE (FR)

International Classes:

A61K38/05; A61K38/08; A61P31/04; A61K38/00; C07K5/078; (IPC1-7): C07K5/078; A61K38/05; A61K38/08

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