Title:
SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/001556
Kind Code:
A1
Abstract:
The present invention relates to a compound as represented by the following general formula, a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, a preparation method therefor, a pharmaceutical composition containing same, and use thereof in the preparation of a medicament for preventing and treating tumors. See description for the definitions of the substituents.
Inventors:
DENG XIANMING (CN)
ZHANG TING (CN)
KANG QIAOFENG (CN)
YANG YANRU (CN)
SUN XIHUAN (CN)
YANG ZAIYOU (CN)
LI XIAOYANG (CN)
ZHANG JINGFANG (CN)
ZHONG JIAJI (CN)
DENG ZHOU (CN)
DONG CHAO (CN)
LIU SHUANG (CN)
LI LI (CN)
XU QINGYAN (CN)
HU ZHIYU (CN)
ZHANG TING (CN)
KANG QIAOFENG (CN)
YANG YANRU (CN)
SUN XIHUAN (CN)
YANG ZAIYOU (CN)
LI XIAOYANG (CN)
ZHANG JINGFANG (CN)
ZHONG JIAJI (CN)
DENG ZHOU (CN)
DONG CHAO (CN)
LIU SHUANG (CN)
LI LI (CN)
XU QINGYAN (CN)
HU ZHIYU (CN)
Application Number:
PCT/CN2018/093544
Publication Date:
January 03, 2019
Filing Date:
June 29, 2018
Export Citation:
Assignee:
UNIV XIAMEN (CN)
International Classes:
C07D473/30; A61K31/519; A61P35/00
Domestic Patent References:
| WO2011090738A2 | 2011-07-28 | |||
| WO2007004749A1 | 2007-01-11 | |||
| WO2016130920A2 | 2016-08-18 |
Foreign References:
| CN103570723A | 2014-02-12 |
Other References:
PERSPICACE, E. ET AL.: "Unexpected C-O Bond Formation in Suzuki Coupling 4- Chlorothieno[2, 3-d]Pyrimidines", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 46, no. 3, 26 May 2009 (2009-05-26), pages 459 - 464, XP055566385, ISSN: 1943-5193
YANG, LINGLING ET AL.: "Structure-Activity Relationship Studies of Pyrazolo[3,4-d]Pyrimidine Derivatives Leading to the Discovery of a Novel Multikinase Inhibitor That Potently Inhibits FLT3 and VEGFR2 and Evaluation of Its Activity against Acute Myeloid Leukemia in Vitro and in Vivo", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 4, 30 January 2013 (2013-01-30), pages 1641 - 1655, XP055266067, ISSN: 0022-2623
TAN, LI ET AL.: "Discovery of Type II Inhibitors of TGFbeta-Activated Kinase 1 (TAKl) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 1, 17 July 2014 (2014-07-17), pages 183 - 196, XP055385149, ISSN: 0022-2623
LAWHORN, B.G. ET AL.: "Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 18, 10 September 2015 (2015-09-10), pages 7431 - 7448, XP055566407, ISSN: 0022-2623
WANG, WEICONG ET AL.: "Development of an UPLC-MS/MS Method for Quantification of Avitinib (AC0010) and Its Five Metabolites in Human Cerebrospinal Fluid: Application to a Study of the Blood-Brain Barrier Penetration Rate of Non-Small Cell Lung Cancer Patients", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 139, 4 March 2017 (2017-03-04), pages 205 - 214, XP029967525, ISSN: 0731-7085
CARPINELLI P ET AL., MOL. CANCER THER., 2007, pages 3158 - 3168
PEDERSEN MW ET AL., BR. J. CANCER., 2005, pages 915 - 923
SUN L ET AL., J. MED. CHEM., 2003, pages 1116 - 1119
MANFRED E. WOLFF: "Burger's Medicinal Chemistry and Drug Discovery", 1995, MACK PUBLISHING COMPANY, pages: 172 - 178,949-982
"Purification of Laboratory Chemicals", 1980, PERGAMON PRESS
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 694499-26-8
PROC. NATL. ACAD. SCI. U S A., vol. 103, 2006, pages 3153 - 8
See also references of EP 3647313A4
YANG, LINGLING ET AL.: "Structure-Activity Relationship Studies of Pyrazolo[3,4-d]Pyrimidine Derivatives Leading to the Discovery of a Novel Multikinase Inhibitor That Potently Inhibits FLT3 and VEGFR2 and Evaluation of Its Activity against Acute Myeloid Leukemia in Vitro and in Vivo", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 4, 30 January 2013 (2013-01-30), pages 1641 - 1655, XP055266067, ISSN: 0022-2623
TAN, LI ET AL.: "Discovery of Type II Inhibitors of TGFbeta-Activated Kinase 1 (TAKl) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 1, 17 July 2014 (2014-07-17), pages 183 - 196, XP055385149, ISSN: 0022-2623
LAWHORN, B.G. ET AL.: "Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 18, 10 September 2015 (2015-09-10), pages 7431 - 7448, XP055566407, ISSN: 0022-2623
WANG, WEICONG ET AL.: "Development of an UPLC-MS/MS Method for Quantification of Avitinib (AC0010) and Its Five Metabolites in Human Cerebrospinal Fluid: Application to a Study of the Blood-Brain Barrier Penetration Rate of Non-Small Cell Lung Cancer Patients", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 139, 4 March 2017 (2017-03-04), pages 205 - 214, XP029967525, ISSN: 0731-7085
CARPINELLI P ET AL., MOL. CANCER THER., 2007, pages 3158 - 3168
PEDERSEN MW ET AL., BR. J. CANCER., 2005, pages 915 - 923
SUN L ET AL., J. MED. CHEM., 2003, pages 1116 - 1119
MANFRED E. WOLFF: "Burger's Medicinal Chemistry and Drug Discovery", 1995, MACK PUBLISHING COMPANY, pages: 172 - 178,949-982
"Purification of Laboratory Chemicals", 1980, PERGAMON PRESS
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 694499-26-8
PROC. NATL. ACAD. SCI. U S A., vol. 103, 2006, pages 3153 - 8
See also references of EP 3647313A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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