Title:
SUBSTITUTED BENZOPYRAN ANALOGS FOR THE TREATMENT OF INFLAMMATION
Document Type and Number:
WIPO Patent Application WO2000023433
Kind Code:
A8
Abstract:
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula (I') wherein X, A<1>, A<2>, A<3>, A<4>, R, R'', R<1> and R<2> are as described in the specification.
Inventors:
CARTER JEFFREY S (US)
DEVADAS BALEKUDRU (US)
TALLEY JOHN J (US)
BROWN DAVID L (US)
GRANETO MATTHEW J (US)
ROGIER DONALD J JR (US)
NAGARAJAN SRINIVASAN R (US)
HANAU CATHLEEN E (US)
HARTMANN SUSAN J (US)
LUDWIG CINDY L (US)
METZ SUZANNE (US)
KORTE DONALD E (US)
BERTENSHAW STEPHEN R (US)
OBUKOWICZ MARK G (US)
DEVADAS BALEKUDRU (US)
TALLEY JOHN J (US)
BROWN DAVID L (US)
GRANETO MATTHEW J (US)
ROGIER DONALD J JR (US)
NAGARAJAN SRINIVASAN R (US)
HANAU CATHLEEN E (US)
HARTMANN SUSAN J (US)
LUDWIG CINDY L (US)
METZ SUZANNE (US)
KORTE DONALD E (US)
BERTENSHAW STEPHEN R (US)
OBUKOWICZ MARK G (US)
Application Number:
PCT/US1999/021460
Publication Date:
July 27, 2000
Filing Date:
October 15, 1999
Export Citation:
Assignee:
SEARLE & CO (US)
CARTER JEFFREY S (US)
DEVADAS BALEKUDRU (US)
TALLEY JOHN J (US)
BROWN DAVID L (US)
GRANETO MATTHEW J (US)
ROGIER DONALD J JR (US)
NAGARAJAN SRINIVASAN R (US)
HANAU CATHLEEN E (US)
HARTMANN SUSAN J (US)
LUDWIG CINDY L (US)
METZ SUZANNE (US)
KORTE DONALD E (US)
BERTENSHAW STEPHEN R (US)
OBUKOWICZ MARK G (US)
CARTER JEFFREY S (US)
DEVADAS BALEKUDRU (US)
TALLEY JOHN J (US)
BROWN DAVID L (US)
GRANETO MATTHEW J (US)
ROGIER DONALD J JR (US)
NAGARAJAN SRINIVASAN R (US)
HANAU CATHLEEN E (US)
HARTMANN SUSAN J (US)
LUDWIG CINDY L (US)
METZ SUZANNE (US)
KORTE DONALD E (US)
BERTENSHAW STEPHEN R (US)
OBUKOWICZ MARK G (US)
International Classes:
A61K31/35; A61K31/352; A61K31/381; A61K31/382; A61K31/4184; A61K31/443; A61K31/4433; A61K31/453; A61K31/47; A61K31/5377; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07D215/54; C07D335/06; C07D221/00; C07D307/00; C07D311/00; C07D311/12; C07D311/22; C07D311/38; C07D311/58; C07D311/92; C07D317/00; C07D401/12; C07D405/04; C07D405/12; C07D407/04; C07D407/12; C07D409/04; C07D413/12; C07D471/04; C07D491/04; C07D491/052; C07D493/04; A61K; C07D; (IPC1-7): C07D311/58; C07D335/06; C07D215/54; C07D311/92; C07D493/04; C07D409/04; C07D491/04; A61K31/35
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