Title:
SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/014351
Kind Code:
A1
Abstract:
Substituted benzylthiazolidine-2,4-dione derivatives capable of, as a ligand of human peroxisome proliferator-activated receptor (PPAR), enhancing the transcriptional activity of the receptor and showing effects of lowering blood sugar level and lowering lipid level; and a process for producing the same. Novel substituted benzamide derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and hydrates of the same wherein A represents optionally substituted phenyl, optionally substituted phenoxy or optionally substituted benzyloxy.
Inventors:
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
TANASE TAKAHIRO (JP)
MURAKAMI KOJI (JP)
TSUNODA MASAKI (JP)
NOMURA MASAHIRO (JP)
TANASE TAKAHIRO (JP)
MURAKAMI KOJI (JP)
TSUNODA MASAKI (JP)
Application Number:
PCT/JP2000/005521
Publication Date:
March 01, 2001
Filing Date:
August 18, 2000
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
TANASE TAKAHIRO (JP)
MURAKAMI KOJI (JP)
TSUNODA MASAKI (JP)
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
TANASE TAKAHIRO (JP)
MURAKAMI KOJI (JP)
TSUNODA MASAKI (JP)
International Classes:
A61P3/06; A61P3/10; A61P43/00; C07D277/34; (IPC1-7): C07D277/34; A61K31/426; A61P3/06; A61P3/10; A61P43/00
Domestic Patent References:
WO1997032863A1 | 1997-09-12 |
Foreign References:
JPH08333355A | 1996-12-17 | |||
JPH0948771A | 1997-02-18 | |||
EP0332331A2 | 1989-09-13 | |||
JPH09301963A | 1997-11-25 |
Other References:
MURAKAMI K. ET AL.: "A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha(PPAR-alpha) and PPAR-gamma", DIABETES, vol. 47, 1998, pages 1841 - 1847, XP002931731
TOMOHIRO IDE ET AL.: "Zucker fatty rat ni okeru kanshishitsu taisha ni taisuru PPARalpha kasseika no eikyou", DIABETES FRONTIER, vol. 9, no. 3, 1998, pages 345 - 346, XP002937010
See also references of EP 1207157A4
TOMOHIRO IDE ET AL.: "Zucker fatty rat ni okeru kanshishitsu taisha ni taisuru PPARalpha kasseika no eikyou", DIABETES FRONTIER, vol. 9, no. 3, 1998, pages 345 - 346, XP002937010
See also references of EP 1207157A4
Attorney, Agent or Firm:
Minoura, Kiyoshi (Kudankita 3-chome Chiyoda-ku Tokyo, JP)
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