Title:
SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005075425
Kind Code:
A3
Abstract:
The present invention relates to bisarylurea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
Inventors:
BUCHSTALLER HANS-PETER (DE)
BURGDORF LARS (DE)
STIEBER FRANK (DE)
AMENDT CHRISTIANE (DE)
GRELL MATTHIAS (DE)
SIRRENBERG CHRISTIAN (DE)
ZENKE FRANK (DE)
BURGDORF LARS (DE)
STIEBER FRANK (DE)
AMENDT CHRISTIANE (DE)
GRELL MATTHIAS (DE)
SIRRENBERG CHRISTIAN (DE)
ZENKE FRANK (DE)
Application Number:
PCT/EP2005/000387
Publication Date:
December 14, 2006
Filing Date:
January 17, 2005
Export Citation:
Assignee:
MERCK PATENT GMBH (DE)
BUCHSTALLER HANS-PETER (DE)
BURGDORF LARS (DE)
STIEBER FRANK (DE)
AMENDT CHRISTIANE (DE)
GRELL MATTHIAS (DE)
SIRRENBERG CHRISTIAN (DE)
ZENKE FRANK (DE)
BUCHSTALLER HANS-PETER (DE)
BURGDORF LARS (DE)
STIEBER FRANK (DE)
AMENDT CHRISTIANE (DE)
GRELL MATTHIAS (DE)
SIRRENBERG CHRISTIAN (DE)
ZENKE FRANK (DE)
International Classes:
C07D401/12; A61K31/435; A61P35/00; C07D213/00; C07D213/68; C07D213/82; C07D409/12
Domestic Patent References:
| WO2003099771A2 | 2003-12-04 | |||
| WO1999032436A1 | 1999-07-01 |
Foreign References:
| US20030144278A1 | 2003-07-31 | |||
| US4191767A | 1980-03-04 |
Other References:
DYCK B ET AL: "Aryl piperazine melanocortin MC4 receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 13, no. 21, 3 November 2003 (2003-11-03), pages 3793 - 3796, XP002279632, ISSN: 0960-894X
KREMER, C.B. ET AL.: "Morpholine condensations", J. AM. CHEM. SOC., vol. 61, 1939, pages 2552 - 2552, XP002387485
KRBECHEK, L. ET AL.: "The thermal decomposition of benzylidene-2-azidoanilines", J. ORG. CHEM., vol. 29, 1964, pages 3630 - 3632, XP002387486
DATABASE BEILSTEIN [online] XP002387488, Database accession no. 163948
KREMER, C.B. ET AL.: "Morpholine condensations", J. AM. CHEM. SOC., vol. 61, 1939, pages 2552 - 2552, XP002387485
KRBECHEK, L. ET AL.: "The thermal decomposition of benzylidene-2-azidoanilines", J. ORG. CHEM., vol. 29, 1964, pages 3630 - 3632, XP002387486
DATABASE BEILSTEIN [online] XP002387488, Database accession no. 163948
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