SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE-TRANSFER PROTEIN (MTP)

Title:

SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE-TRANSFER PROTEIN (MTP)

Document Type and Number:

WIPO Patent Application WO2001021604

Kind Code:

A8

Abstract:

The invention relates to substituted piperazine derivatives of general formula (I), in which: n represents the number 1, 2, 3, 4, or 5; m represents the number 2 or 3; X represents a carbon-carbon bond, an oxygen atom, a methylene group, an ethylene group, an imino group, or an N-(C1-3 alkyl)imino group; Ra represents a substituted phenyl group or heteroaryl group; Rb and Rc, independent of one another, represent a hydrogen atom or a C1-3 alkyl group; Rf and Rg, which can be the same or different, represent a hydrogen atom, C1-6 alkyl groups, C3-7 cycloalkyl groups, phenyl, heteroaryl, phenyl C1-3 alkyl groups or heteroaryl C1-3 alkyl groups; Rf and Rg, together with the nitrogen atom located therebetween, represent a 3-member to 7-member cycloalkylene imino group, whereby the methylene group can be additionally replaced in position 4 located in a 6-member or 7-member cycloalkenylene imino group by an oxygen atom or sulfur atom, by a sulfinyl group, a sulfonyl group, an imino group or by an N-(C1-3 alkyl)imino group. The invention also relates to the isomers and salts of the inventive piperazine derivatives, in particular, to the physiologically compatible salts thereof which depict valuable inhibitors of the microsomal triglyceride-transfer protein (MTP). The invention additionally relates to medicaments containing these compounds, to the use thereof and to their production.

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Inventors:

LEHMANN-LINTZ THORSTEN (DE)
HECKEL ARMIN (DE)
THOMAS LEO (DE)
MARK MICHAEL (DE)

Application Number:

PCT/EP2000/009146

Publication Date:

July 12, 2001

Filing Date:

September 19, 2000

Export Citation:

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Assignee:

BOEHRINGER INGELHEIM PHARMA (DE)
LEHMANN LINTZ THORSTEN (DE)
HECKEL ARMIN (DE)
THOMAS LEO (DE)
MARK MICHAEL (DE)

International Classes:

C07D295/14; A61K31/495; A61K31/496; A61K31/506; A61P1/18; A61P3/06; A61P3/10; A61P9/10; C07D207/335; C07D213/38; C07D213/74; C07D233/54; C07D233/64; C07D239/42; C07D263/48; C07D277/28; C07D285/08; C07D295/145; C07D333/20; C07D333/36; C07D401/04; C07D207/32; (IPC1-7): C07D295/14; A61K31/495; A61K31/505; A61K31/55; A61P3/06; A61P3/10; A61P9/10; C07D207/32; C07D213/38; C07D213/74; C07D233/54; C07D239/42; C07D263/48; C07D277/28; C07D285/08; C07D333/20; C07D333/36; C07D405/12

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