Title:
SUBSTRATE FOR MALDI-TOF MS AND MASS SPECTROMETRY METHOD USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2006/046697
Kind Code:
A1
Abstract:
A substrate for MALDI-TOF MS whereby even a high-molecular weight substance such as a protein or a nucleic acid can be analyzed by mass spectrometry at a high reproducibility and a mass spectrum can be easily obtained; and a mass spectrometry method by MALDI-TOF MS by using the same. This substrate for MALDI-TOF MS has a nanodot region for adhering a test substance thereto the surface of which is made of a material having a high protein or nucleic acid absorptivity. A mass spectrometry method for analyzing a protein or a nucleic acid which comprises using this substrate and performing mass spectrometry by MALDI-TOF MS with the use of the nucleic acid or the protein as a test sample.
Inventors:
HONDA AKI (JP)
SUZUKI KOJI (JP)
SUZUKI KOJI (JP)
Application Number:
PCT/JP2005/019900
Publication Date:
May 04, 2006
Filing Date:
October 28, 2005
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
HONDA AKI (JP)
SUZUKI KOJI (JP)
HONDA AKI (JP)
SUZUKI KOJI (JP)
International Classes:
G01N27/62; G01N1/10; G01N1/28; G01N27/64
Foreign References:
| JP2004184137A | 2004-07-02 | |||
| JP2004125785A | 2004-04-22 | |||
| JP2003247983A | 2003-09-05 | |||
| JP2001013110A | 2001-01-19 | |||
| JP2004266100A | 2004-09-24 | |||
| US6743607B2 | 2004-06-01 | |||
| US6693187B1 | 2004-02-17 | |||
| US20030220254A1 | 2003-11-27 | |||
| US20020121595A1 | 2002-09-05 |
Other References:
SCHUERENBERG M. ET AL: "Prestructured MALDI-MS Sample Supports", ANALYTICAL CHEMISTRY, vol. 72, no. 15, 1 August 2000 (2000-08-01), pages 3436 - 3442, XP002995250
KOOMEN, J. ET AL., ANAL. CHEM., vol. 72, 2000, pages 3860
VORM, O. ET AL., ANAL. CHEM., vol. 66, 1994, pages 3287
BERGGREN, W. T. ET AL., ANAL. CHEM., vol. 74, 2002, pages 1745
PAPAC, D. I. ET AL., ANAL. CHEM., vol. 68, 1996, pages 3215
HUNG, K. C. ET AL., ANAL. CHEM., vol. 70, 1998, pages 3088
KOOMEN, J. ET AL., ANAL. CHEM., vol. 72, 2000, pages 3860
VORM, O. ET AL., ANAL. CHEM., vol. 66, 1994, pages 3287
BERGGREN, W. T. ET AL., ANAL. CHEM., vol. 74, 2002, pages 1745
PAPAC, D. I. ET AL., ANAL. CHEM., vol. 68, 1996, pages 3215
HUNG, K. C. ET AL., ANAL. CHEM., vol. 70, 1998, pages 3088
Attorney, Agent or Firm:
Tanigawa, Hidejiro c/o TANIGAWA AND ASSOCIATES (Patent Firm 6F, Iwata Bldg.,, 5-12, Iidabashi 4-chome, Chiyoda-ku Tokyo, JP)
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