Title:
SUGAR CHAIN-MODIFIED ANTI-HM1.24 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2005/014651
Kind Code:
A1
Abstract:
Sugar chain modification makes it possible to provide the following antibody having enhanced antibody-dependent cellular cytotoxicity (ADCC), i.e., an antibody having a sugar chain free from an antibody against HM1.24 antigen (anti-HM1.24 antibody, more specifically speaking, &agr -1,6 core fucose), an antibody having a sugar chain having a bisecting N-acetylglucosamine (GlcNAc) structure, or an antibody having a sugar chain free from &agr -1,6 core fucose and having a sugar chain having a bisecting N-acetylglucosamine (GlcNAc) structure.
Inventors:
TSUCHIYA MASAYUKI (JP)
IIJIMA SHIGEYUKI (JP)
SUGO IZUMI (JP)
SUGIMOTO MASAMICHI (JP)
IIJIMA SHIGEYUKI (JP)
SUGO IZUMI (JP)
SUGIMOTO MASAMICHI (JP)
Application Number:
PCT/JP2004/011812
Publication Date:
February 17, 2005
Filing Date:
August 11, 2004
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
TSUCHIYA MASAYUKI (JP)
IIJIMA SHIGEYUKI (JP)
SUGO IZUMI (JP)
SUGIMOTO MASAMICHI (JP)
TSUCHIYA MASAYUKI (JP)
IIJIMA SHIGEYUKI (JP)
SUGO IZUMI (JP)
SUGIMOTO MASAMICHI (JP)
International Classes:
C07K16/30; C12N15/12; C12P21/08; (IPC1-7): C07K16/30; C12N15/12; C12P21/08
Domestic Patent References:
| WO1998037913A1 | 1998-09-03 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2002079255A1 | 2002-10-10 | |||
| WO1999054342A1 | 1999-10-28 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2002079255A1 | 2002-10-10 | |||
| WO1998014580A1 | 1998-04-09 |
Foreign References:
| JPH10286088A | 1998-10-27 | |||
| JP2002512014A | 2002-04-23 |
Other References:
See also references of EP 1666501A4
ISHIKAWA J. ET AL., GENOMICS, vol. 26, 1995, pages 527 - 534
GOTO T. ET AL., BLOOD, vol. 84, 1994, pages 1922 - 1930
OZAKI S. ET AL., BLOOD, vol. 90, 1997, pages 3179 - 3186
OZAKI S ET AL., BLOOD
AMERICAN SOCIETY OF HEMATOLOGY, vol. 93, no. 11, 1 June 1999 (1999-06-01), pages 3922 - 3930
SHIELDS ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY
AMERICAN SOCIETY OF BIOCHEMICAL BIOLOGISTS, BIRMINGHAM, vol. 277, no. 30, pages 26733 - 26740
ISHIKAWA J. ET AL., GENOMICS, vol. 26, 1995, pages 527 - 534
GOTO T. ET AL., BLOOD, vol. 84, 1994, pages 1922 - 1930
OZAKI S. ET AL., BLOOD, vol. 90, 1997, pages 3179 - 3186
OZAKI S ET AL., BLOOD
AMERICAN SOCIETY OF HEMATOLOGY, vol. 93, no. 11, 1 June 1999 (1999-06-01), pages 3922 - 3930
SHIELDS ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY
AMERICAN SOCIETY OF BIOCHEMICAL BIOLOGISTS, BIRMINGHAM, vol. 277, no. 30, pages 26733 - 26740
Attorney, Agent or Firm:
Aoki, Atsushi (ISHIDA & ASSOCIATES Toranomon 37 Mori
Bldg., 5-1, Toranomon 3-chome, Minato-k, Tokyo, JP)
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