Title:
SULFATED BIS-CYCLIC AGENTS
Document Type and Number:
WIPO Patent Application WO2004103961
Kind Code:
A3
Abstract:
Sulfated bis-cyclic compounds that are potent anticoagulants and methods for their manufacture are provided. The sulfated compounds are bis-cyclic moieties comprised o an ioquinoline ring joined to a phenyl ring with the general chemical structure formula (I) where R2 is hydrogen or a sulfate moiety, R3 is either hydrogen or carboxylate moiety; R4 is a hydrogen or oxygen; and R5 is a hydrogen if R4 is a hydrogen, and is absent if R4 is oxygen. Counterions such as sodium may also be coordinated to the sulfate and carboxylate moieties.
Inventors:
DESAI UMESH R (US)
GUNNARSSON GUNNAR (US)
GUNNARSSON GUNNAR (US)
Application Number:
PCT/US2004/015731
Publication Date:
April 14, 2005
Filing Date:
May 19, 2004
Export Citation:
Assignee:
UNIV VIRGINIA COMMONWEALTH (US)
DESAI UMESH R (US)
GUNNARSSON GUNNAR (US)
DESAI UMESH R (US)
GUNNARSSON GUNNAR (US)
International Classes:
A61K31/47; C07D217/04; C07D217/06; C07D217/26; C07D; (IPC1-7): C07D217/04; A61K31/47
Other References:
GUNNARSSOM G.T. ET AL: "Designing Small, Nonsugar Activators of Antithrobin Using Hydropathic Interaction Analyses", J. MED. CHEM., vol. 45, 2000, pages 1233 - 1243, XP002985063
GUNNARSSON G.T. ET AL: "Interaction of Designed Sulfated Flavanoids with Antithrombin: LEssons on the Design of Organic Activators", J. MED. CHEM., vol. 45, 2002, pages 4460 - 4470, XP002985064
GUNNARSSON G.T. ET AL: "Interaction of Designed Sulfated Flavanoids with Antithrombin: LEssons on the Design of Organic Activators", J. MED. CHEM., vol. 45, 2002, pages 4460 - 4470, XP002985064
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