Title:
SUPPORTED MOLECULAR BIOFLUID VISCOSITY SENSORS FOR IN VITRO AND IN VIVO USE
Document Type and Number:
WIPO Patent Application WO2005072216
Kind Code:
A3
Abstract:
A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.
Inventors:
HAIDEKKER MARK A (US)
GRANT SHEILA (US)
THEODORAKIS EMMANUEL
INTAGLIETTA MARCOS
FRANGOS JOHN
GRANT SHEILA (US)
THEODORAKIS EMMANUEL
INTAGLIETTA MARCOS
FRANGOS JOHN
Application Number:
PCT/US2005/001736
Publication Date:
December 01, 2005
Filing Date:
January 20, 2005
Export Citation:
Assignee:
UNIV MISSOURI (US)
HAIDEKKER MARK A (US)
GRANT SHEILA (US)
THEODORAKIS EMMANUEL
INTAGLIETTA MARCOS
FRANGOS JOHN
HAIDEKKER MARK A (US)
GRANT SHEILA (US)
THEODORAKIS EMMANUEL
INTAGLIETTA MARCOS
FRANGOS JOHN
International Classes:
A61B5/00; G01N11/14; G01N21/76; G01N11/00; (IPC1-7): G01N21/76
Domestic Patent References:
| WO2002086472A1 | 2002-10-31 |
Other References:
HAIDEKKER M. ET AL.: "A novel approach to blood plasma viscosity measurement using fluorescent molecular rotors.", AMERICAN JOURNAL OF PHYSIOLOGY., vol. 282, 2002, pages 1609 - 1614
KUNG C. ET AL.: "Fluorescent Molecular Rotors: A new Class of Probes for Tubulin Structure and Assembly.", BIOCHEMISTRY, vol. 28, 1989, pages 6678 - 6686
LOUTFY R. ET AL.: "Effect of Viscosity and Temperature on Torsional Relaxation of Molecular Rotors.", J. PHYS. CHEM., vol. 86, 1982, pages 4205 - 4211
KUNG C. ET AL.: "Fluorescent Molecular Rotors: A new Class of Probes for Tubulin Structure and Assembly.", BIOCHEMISTRY, vol. 28, 1989, pages 6678 - 6686
LOUTFY R. ET AL.: "Effect of Viscosity and Temperature on Torsional Relaxation of Molecular Rotors.", J. PHYS. CHEM., vol. 86, 1982, pages 4205 - 4211
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