Title:
SYNDECANS AND ANGIOGENESIS
Document Type and Number:
WIPO Patent Application WO2003062386
Kind Code:
A3
Abstract:
The invention provides methods and materials related to modulating syndecan levels and angiogenesis in an animal. The invention provides syndecan polypeptides and nucleic acids encoding syndecan polypeptides. The invention also provides polynucleotides and polynucleotide analogues for modulating angiogenesis, as well as cells and embryos containing the polynucleotides and polynucleotide analogues. The invention further provides methods for identifying syndecan- and angiogenesis-modulating agents.
Inventors:
EKKER STEPHEN C (US)
CHEN ELEANOR Y (US)
CHEN ELEANOR Y (US)
Application Number:
PCT/US2003/001637
Publication Date:
December 04, 2003
Filing Date:
January 17, 2003
Export Citation:
Assignee:
UNIV MINNESOTA (US)
EKKER STEPHEN C (US)
CHEN ELEANOR Y (US)
EKKER STEPHEN C (US)
CHEN ELEANOR Y (US)
International Classes:
C07K14/46; C07K14/705; C12N15/113; A61K38/00; (IPC1-7): C07H21/04; A61K48/00; C12N15/00
Other References:
MODROWSKI ET AL.: "Syndecan-2 is involved in the mitogenic activity and signaling of granulocyte-macrophage colony-stimulating factor in osteoblasts", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 13, 31 March 2000 (2000-03-31), pages 9178 - 9185, XP002965975
DOBRA ET AL.: "Differentiation of mseothelioma cells is influenced by the expression of proteoglycans", vol. 258, 2000, pages 12 - 22, XP002965976
KUSANO ET AL.: "Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1: structural characteristics of heparin sulfate chains with avidity to COOH-terminal heparin-binding domain of fibronectin", vol. 256, 2000, pages 434 - 444, XP002965977
DOBRA ET AL.: "Differentiation of mseothelioma cells is influenced by the expression of proteoglycans", vol. 258, 2000, pages 12 - 22, XP002965976
KUSANO ET AL.: "Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1: structural characteristics of heparin sulfate chains with avidity to COOH-terminal heparin-binding domain of fibronectin", vol. 256, 2000, pages 434 - 444, XP002965977
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