Title:
T CELL RECEPTOR-LIKE ANTIBODIES SPECIFIC FOR A PRAME PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2016/191246
Kind Code:
A3
Abstract:
The presently disclosed subject matter provides antigen-binding proteins that specifically bind to Preferentially expressed antigen of melanoma (PRAME), including humanized, chimeric and fully human antibodies against PRAME, antibody fragments (e.g., scFv, Fab and F(ab)2), chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen-binding proteins and antibodies bind to a PRAME peptide/HLA class I molecule complex. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of PRAME associated diseases, including for example, breast cancer, ovarian cancer, melanoma, lung cancer, gastrointestinal cancer, brain tumor, head and neck cancer, renal cancer, myeloma, neuroblastoma, mantle cell lymphoma, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML), Non-Hodgkin lymphoma (NHL), and Chronic lymphocytic leukemia (CLL). The antibodies or antigen binding proteins may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels.
Inventors:
SCHEINBERG DAVID A (US)
DAO TAO (US)
LIU CHENG (US)
LIU HONG (US)
XU YIYANG (US)
YAN SU (US)
DAO TAO (US)
LIU CHENG (US)
LIU HONG (US)
XU YIYANG (US)
YAN SU (US)
Application Number:
PCT/US2016/033430
Publication Date:
April 27, 2017
Filing Date:
May 20, 2016
Export Citation:
Assignee:
MEMORIAL SLOAN KETTERING CANCER CENTER (US)
EUREKA THERAPEUTICS INC (US)
EUREKA THERAPEUTICS INC (US)
International Classes:
A61K39/395; C07K16/18; C07K16/28; C07K16/30
Domestic Patent References:
| WO2011147982A2 | 2011-12-01 |
Foreign References:
| US20130029359A1 | 2013-01-31 | |||
| US20140348862A1 | 2014-11-27 | |||
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| US20070004910A1 | 2007-01-04 | |||
| US20100303801A1 | 2010-12-02 | |||
| US20080095775A1 | 2008-04-24 |
Other References:
KESSLER ET AL.: "Efficient Identification of Novel Hla-A*0201-Presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen Prame by Proteasome-Mediated Digestion Analysis.", J EXP MED., vol. 193, no. 1, 1 January 2001 (2001-01-01), pages 73 - 88, XP002339970
DATABASE GenPept 21 January 2000 (2000-01-21), "Ig lambda chain - human (fragment)", XP055501460, Database accession no. S25754
DATABASE UniProtKB/TrEMBL [o] 1 April 2015 (2015-04-01), Database accession no. A2NYV5_HUMAN
DATABASE GenPept 21 January 2000 (2000-01-21), "Ig lambda chain - human (fragment)", XP055501460, Database accession no. S25754
DATABASE UniProtKB/TrEMBL [o] 1 April 2015 (2015-04-01), Database accession no. A2NYV5_HUMAN
Attorney, Agent or Firm:
KOLE, Lisa, B. et al. (US)
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