Title:
TARGETING ANTIGEN-SPECIFIC T CELLS FOR SPECIFIC IMMUNOTHERAPY OF AUTOIMMUNE DISEASE
Document Type and Number:
WIPO Patent Application WO1999029883
Kind Code:
A3
Abstract:
Antigen-specific T cells are stimulated to proliferate by activation with properly presented antigen. Targeting a detrimental product to only those cells which are stimulated to proliferate in response to the antigen presentation permits the selective and highly efficient ablation of a key component of the disease symptomology of myasthenia gravis.
Inventors:
DRACHMAN DANIEL B
Application Number:
PCT/US1998/025575
Publication Date:
August 26, 1999
Filing Date:
December 03, 1998
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
International Classes:
A61K39/00; A61P37/06; C12N15/12; A61K48/00; (IPC1-7): C12N15/86; C12N15/12; A61K48/00; C12N5/10
Domestic Patent References:
| WO1996031603A2 | 1996-10-10 | |||
| WO1996024671A1 | 1996-08-15 |
Other References:
DRACHMAN ET AL: "IMMUNOTHERAPY IN NEUROMUSCULAR DISORDERS: CURRENT AND FUTURE STRATEGIES", MUSCLE AND NERVE, vol. 19, 1996, pages 1239 - 1251, XP002107125
SHYR-TE JU ET AL: "FAS(CD95)/FASL INTERACTIONS REQUIRED FOR PROGRAMMED CELL DEATH AFTER T-CELL ACTIVATION", NATURE, vol. 373, 2 February 1995 (1995-02-02), pages 444 - 448, XP002030470
REIM ET AL: "SPECIFIC IMMUNOTHERAPEUTIC STRATEGY FOR MYASTHENIA GRAVIS: TARGETED ANTIGEN-PRESENTING CELLS", JOURNAL OF NEUROIMMUNOLOGY, vol. 41, 1992, pages 61 - 70, XP002107126
DRACHMAN ET AL: "STRATEGIES FOR TREATMENT OF MYASTHENIA GRAVIS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 681, 1993, pages 515 - 528, XP002107127
DATABASE MEDLINE FILE SERVER STN KARLSRUHE; MCINTOSH K R ET AL: "Immunosuppression and induction of anergy by CTLA4Ig in vitro: effects on cellular and antibody responses of lymphocytes from rats with experimental autoimmune myasthenia gravis.", XP002107128
SHYR-TE JU ET AL: "FAS(CD95)/FASL INTERACTIONS REQUIRED FOR PROGRAMMED CELL DEATH AFTER T-CELL ACTIVATION", NATURE, vol. 373, 2 February 1995 (1995-02-02), pages 444 - 448, XP002030470
REIM ET AL: "SPECIFIC IMMUNOTHERAPEUTIC STRATEGY FOR MYASTHENIA GRAVIS: TARGETED ANTIGEN-PRESENTING CELLS", JOURNAL OF NEUROIMMUNOLOGY, vol. 41, 1992, pages 61 - 70, XP002107126
DRACHMAN ET AL: "STRATEGIES FOR TREATMENT OF MYASTHENIA GRAVIS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 681, 1993, pages 515 - 528, XP002107127
DATABASE MEDLINE FILE SERVER STN KARLSRUHE; MCINTOSH K R ET AL: "Immunosuppression and induction of anergy by CTLA4Ig in vitro: effects on cellular and antibody responses of lymphocytes from rats with experimental autoimmune myasthenia gravis.", XP002107128
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