TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS

Title:

TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS

Document Type and Number:

WIPO Patent Application WO2004056779

Kind Code:

A3

Abstract:

The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein Rand R<2> are H, Me; R<3> is (2-6C)heterocycloalkyl(1-4C)alkyl, (2-5C)heteroaryl(1-4C)alkyl, (6C)aryl (1-4C)alkyl, (1-4C)(di)alkylaminocarbonylamino(2-4C)alkyl, (2-6C) heterocycloalkylcarbonylamino(2-4C)alkyl, R<5>-(2-4C)alkyl or R<5>-carbonyl(1-4C)alkyl; R<4> is (2-5C)heteroaryl, (6C)aryl, (3-8C)cycloalkyl, (2-6C)heterocycloalkyl or (1-6C) alkyl and R<5> is (di)(1-4C)alkylamino, (1-4C)alkoxy, amino, hydroxy, (6C)arylamino, (di)(3-4C)alkenylamino, (2-5C)heteroaryl(1-4C)alkylamino, (6C)aryl(1-4C) alkylamino, (di)[(1-4C)alkoxy(2-4C)alkyl]amino, (di)[(1-4C)alkylamino(2-4C) alkyl]amino, (di)[amino(2-4C)alkyl]amino or (di)[hydroxy(2-4C)alkyl]amino. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to regulate fertility.

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Inventors:

TIMMERS CORNELIS MARIUS (NL)
KARSTENS WILLEM FREDERIK JOHAN (NL)

Application Number:

PCT/EP2003/051024

Publication Date:

August 12, 2004

Filing Date:

December 16, 2003

Export Citation:

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Assignee:

AKZO NOBEL NV (NL)
TIMMERS CORNELIS MARIUS (NL)
KARSTENS WILLEM FREDERIK JOHAN (NL)

International Classes:

A61K31/47; A61P5/08; C07D215/38; C07D401/12; C07D409/12; (IPC1-7): C07D215/38; A61K31/47; A61P5/08; C07D401/12; C07D409/12

Domestic Patent References:

WO2000008015A2

2000-02-17

Foreign References:

US6200963B1

2001-03-13

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