Title:
THERAPEUTIC COMBINATIONS OF ATYPICAL ANTIPSYCHOTICS WITH GABA MODULATORS, ANTICONVULSANTS OR BENZODIAZAPINES
Document Type and Number:
WIPO Patent Application WO2004100992
Kind Code:
A3
Abstract:
This invention relates to combinations of an atypical antipsychotic, and a GABA modulator, a benzodiazepine, and/or an anticonvulsant drug, kits containing such combinations, pharmaceutical compositions comprising such combinations, and methods of using such combinations to treat patients suffering from treatment-resistant anxiety disorders, psychotic disorders or conditions, or mood disorders or conditions.
Inventors:
ROMANO STEVEN JOSEPH (US)
Application Number:
PCT/IB2004/001517
Publication Date:
January 20, 2005
Filing Date:
May 03, 2004
Export Citation:
Assignee:
PFIZER PROD INC (US)
ROMANO STEVEN JOSEPH (US)
ROMANO STEVEN JOSEPH (US)
International Classes:
A61K31/496; A61K31/519; A61K31/5513; A61K45/06; A61P25/18; A61P25/22; A61P25/24; (IPC1-7): A61K45/06; A61P25/18; A61P25/22; A61P25/24
Foreign References:
| US20030055008A1 | 2003-03-20 |
Other References:
CALABRESE J R ET AL: "Lamotrigine and clozapine for bipolar disorder.", THE AMERICAN JOURNAL OF PSYCHIATRY. SEP 2000, vol. 157, no. 9, September 2000 (2000-09-01), pages 1523, XP001182678, ISSN: 0002-953X
DEMBOWSKI C ET AL: "Successful antimanic treatment and mood stabilization with lamotrigine, clozapine, and valproate in a bipolar patient after lithium-induced cerebellar deterioration. A case report.", PHARMACOPSYCHIATRY, vol. 36, no. 2, March 2003 (2003-03-01) - April 2003 (2003-04-01), pages 83 - 86, XP009035208, ISSN: 0176-3679
DURSUN S M ET AL: "When treating patients with schizophrenia, what clinical points should be considered if lamotrigine is chosen to augment clozapine?", JOURNAL OF PSYCHIATRY & NEUROSCIENCE : JPN. MAR 2001, vol. 26, no. 2, March 2001 (2001-03-01) - April 2003 (2003-04-01), pages 168, XP009035225, ISSN: 1180-4882
SABA G ET AL: "Lamotrigine--clozapine combination in refractory schizophrenia: three cases.", THE JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES. 2002 WINTER, vol. 14, no. 1, January 2002 (2002-01-01), pages 86, XP009035226, ISSN: 0895-0172
DURSUN S M ET AL: "Clozapine plus lamotrigine in treatment-resistant schizophrenia.", ARCHIVES OF GENERAL PSYCHIATRY. OCT 1999, vol. 56, no. 10, October 1999 (1999-10-01), pages 950, XP009035205, ISSN: 0003-990X
PAVULURI MANI N ET AL: "Topiramate plus risperidone for controlling weight gain and symptoms in preschool mania.", JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY. 2002 FALL, vol. 12, no. 3, October 2002 (2002-10-01), pages 271 - 273, XP009035227, ISSN: 1044-5463
NAVARRO VICTOR ET AL: "Topiramate for clozapine-induced seizures", AMERICAN JOURNAL OF PSYCHIATRY, vol. 158, no. 6, June 2001 (2001-06-01), pages 968 - 969, XP001095768, ISSN: 0002-953X
LESSIG M C ET AL: "TOPIRAMATE FOR REVERSING ATYPICAL ANTIPSYCHOTIC WEIGHT GAIN", JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, THE ACADEMY,, US, vol. 40, no. 12, December 2001 (2001-12-01), pages 1364, XP001104890, ISSN: 0890-8567
WANG PO W ET AL: "Gabapentin augmentation therapy in bipolar depression.", BIPOLAR DISORDERS. OCT 2002, vol. 4, no. 5, October 2002 (2002-10-01), pages 296 - 301, XP001182675, ISSN: 1398-5647
LEVY EMMANUELLE ET AL: "Topiramate produced weight loss following olanzapine-induced weight gain in schizophrenia.", THE JOURNAL OF CLINICAL PSYCHIATRY. NOV 2002, vol. 63, no. 11, November 2002 (2002-11-01), pages 1045, XP009035229, ISSN: 0160-6689
DURSUN S M ET AL: "AUGMENTING ANTIPSYCHOTIC TREATMENT WITH LAMOTRIGINE OR TOPIRAMATE IN PATIENTS WITH TREATMENT-RESISTANT SCHIZOPHRENIA: A NATURALISTIC CASE-SERIES OUTCOME STUDY", JOURNAL OF PSYCHOPHARMACOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 15, no. 4, December 2001 (2001-12-01), pages 297 - 301, XP001097341, ISSN: 0269-8811
BEELEN A P ET AL: "Asymptomatic QTc prolongation associated with quetiapine fumarate overdose in a patient being treated with risperidone", HUMAN AND EXPERIMENTAL TOXICOLOGY, MCMILLAN, BASINGSTOKE, GB, vol. 20, no. 4, April 2001 (2001-04-01), pages 215 - 219, XP001097321, ISSN: 0960-3271
DEMBOWSKI C ET AL: "Successful antimanic treatment and mood stabilization with lamotrigine, clozapine, and valproate in a bipolar patient after lithium-induced cerebellar deterioration. A case report.", PHARMACOPSYCHIATRY, vol. 36, no. 2, March 2003 (2003-03-01) - April 2003 (2003-04-01), pages 83 - 86, XP009035208, ISSN: 0176-3679
DURSUN S M ET AL: "When treating patients with schizophrenia, what clinical points should be considered if lamotrigine is chosen to augment clozapine?", JOURNAL OF PSYCHIATRY & NEUROSCIENCE : JPN. MAR 2001, vol. 26, no. 2, March 2001 (2001-03-01) - April 2003 (2003-04-01), pages 168, XP009035225, ISSN: 1180-4882
SABA G ET AL: "Lamotrigine--clozapine combination in refractory schizophrenia: three cases.", THE JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES. 2002 WINTER, vol. 14, no. 1, January 2002 (2002-01-01), pages 86, XP009035226, ISSN: 0895-0172
DURSUN S M ET AL: "Clozapine plus lamotrigine in treatment-resistant schizophrenia.", ARCHIVES OF GENERAL PSYCHIATRY. OCT 1999, vol. 56, no. 10, October 1999 (1999-10-01), pages 950, XP009035205, ISSN: 0003-990X
PAVULURI MANI N ET AL: "Topiramate plus risperidone for controlling weight gain and symptoms in preschool mania.", JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY. 2002 FALL, vol. 12, no. 3, October 2002 (2002-10-01), pages 271 - 273, XP009035227, ISSN: 1044-5463
NAVARRO VICTOR ET AL: "Topiramate for clozapine-induced seizures", AMERICAN JOURNAL OF PSYCHIATRY, vol. 158, no. 6, June 2001 (2001-06-01), pages 968 - 969, XP001095768, ISSN: 0002-953X
LESSIG M C ET AL: "TOPIRAMATE FOR REVERSING ATYPICAL ANTIPSYCHOTIC WEIGHT GAIN", JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, THE ACADEMY,, US, vol. 40, no. 12, December 2001 (2001-12-01), pages 1364, XP001104890, ISSN: 0890-8567
WANG PO W ET AL: "Gabapentin augmentation therapy in bipolar depression.", BIPOLAR DISORDERS. OCT 2002, vol. 4, no. 5, October 2002 (2002-10-01), pages 296 - 301, XP001182675, ISSN: 1398-5647
LEVY EMMANUELLE ET AL: "Topiramate produced weight loss following olanzapine-induced weight gain in schizophrenia.", THE JOURNAL OF CLINICAL PSYCHIATRY. NOV 2002, vol. 63, no. 11, November 2002 (2002-11-01), pages 1045, XP009035229, ISSN: 0160-6689
DURSUN S M ET AL: "AUGMENTING ANTIPSYCHOTIC TREATMENT WITH LAMOTRIGINE OR TOPIRAMATE IN PATIENTS WITH TREATMENT-RESISTANT SCHIZOPHRENIA: A NATURALISTIC CASE-SERIES OUTCOME STUDY", JOURNAL OF PSYCHOPHARMACOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 15, no. 4, December 2001 (2001-12-01), pages 297 - 301, XP001097341, ISSN: 0269-8811
BEELEN A P ET AL: "Asymptomatic QTc prolongation associated with quetiapine fumarate overdose in a patient being treated with risperidone", HUMAN AND EXPERIMENTAL TOXICOLOGY, MCMILLAN, BASINGSTOKE, GB, vol. 20, no. 4, April 2001 (2001-04-01), pages 215 - 219, XP001097321, ISSN: 0960-3271
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