Title:
THERAPEUTIC COMPOSITIONS FOR SKIN DISORDERS AND WOUND REPAIR
Document Type and Number:
WIPO Patent Application WO/2023/212179
Kind Code:
A3
Abstract:
Disclosed herein are therapeutics compositions including one or more active agents, for instance a statin, cyclodextrin, or combination thereof. The compositions are useful in the treatment of tissue injuries, including wounds, as well as skin inflammation and infections.
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Inventors:
JOZIC IVAN (US)
TOMIC MARJANA (US)
ANDREOPOULOS FOTIOS M (US)
TOMIC MARJANA (US)
ANDREOPOULOS FOTIOS M (US)
Application Number:
PCT/US2023/020173
Publication Date:
January 18, 2024
Filing Date:
April 27, 2023
Export Citation:
Assignee:
UNIV MIAMI (US)
International Classes:
A61K9/10; A61K9/16; A61K47/40; A61K47/42; A61K49/18; A61L27/54; B01J13/00
Domestic Patent References:
| WO2021250205A1 | 2021-12-16 |
Foreign References:
| US20180186939A1 | 2018-07-05 | |||
| US5472954A | 1995-12-05 |
Other References:
ZHOU XINGWU, LUO ZHIMIN, BAIDYA AVIJIT, KIM HAN‐JUN, WANG CANRAN, JIANG XING, QU MOYUAN, ZHU JIXIANG, REN LI, VAJHADIN FERESHTEH, : "Biodegradable β ‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 9, no. 11, 1 June 2020 (2020-06-01), DE , XP093130583, ISSN: 2192-2640, DOI: 10.1002/adhm.202000527
JAIN MEHAK, NOWAK BENEDIKT P., RAVOO BART JAN: "Supramolecular Hydrogels Based on Cyclodextrins: Progress and Perspectives", CHEMNANOMAT, WILEY-VCH, vol. 8, no. 5, 1 May 2022 (2022-05-01), pages 1 - 18, XP093130589, ISSN: 2199-692X, DOI: 10.1002/cnma.202200077
SARFRAZ RAI MUHAMMAD, AHMAD MAHMOOD, MAHMOOD ASIF, AKRAM MUHAMMAD ROUF, ABRAR ASAD: "Development of β-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in vivo evaluation", DRUG DESIGN, DEVELOPMENT AND THERAPY, DOVE MEDICAL PRESS LTD., UNITED KINGDOM, vol. Volume 11, United Kingdom , pages 3083 - 3096, XP093130596, ISSN: 1177-8881, DOI: 10.2147/DDDT.S143712
LIU JIAYUE, TIAN BINGREN, LIU YUMEI, WAN JIAN-BO: "Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 22, no. 24, 1 December 2021 (2021-12-01), Basel, CH , pages 13516, XP093031340, ISSN: 1661-6596, DOI: 10.3390/ijms222413516
MINDUR JOHN E., SWIRSKI FILIP K.: "Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 39, no. 7, 1 July 2019 (2019-07-01), pages 1275 - 1287, XP093130601, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.119.311994
DR. AXE: "Beef Gelatin: What Are the Benefits & How Does It Compare to Collagen?", DRAXE.COM, DRAXE.COM, 22 February 2021 (2021-02-22), pages 1 - 7, XP093130608, Retrieved from the Internet
JAIN MEHAK, NOWAK BENEDIKT P., RAVOO BART JAN: "Supramolecular Hydrogels Based on Cyclodextrins: Progress and Perspectives", CHEMNANOMAT, WILEY-VCH, vol. 8, no. 5, 1 May 2022 (2022-05-01), pages 1 - 18, XP093130589, ISSN: 2199-692X, DOI: 10.1002/cnma.202200077
SARFRAZ RAI MUHAMMAD, AHMAD MAHMOOD, MAHMOOD ASIF, AKRAM MUHAMMAD ROUF, ABRAR ASAD: "Development of β-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in vivo evaluation", DRUG DESIGN, DEVELOPMENT AND THERAPY, DOVE MEDICAL PRESS LTD., UNITED KINGDOM, vol. Volume 11, United Kingdom , pages 3083 - 3096, XP093130596, ISSN: 1177-8881, DOI: 10.2147/DDDT.S143712
LIU JIAYUE, TIAN BINGREN, LIU YUMEI, WAN JIAN-BO: "Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 22, no. 24, 1 December 2021 (2021-12-01), Basel, CH , pages 13516, XP093031340, ISSN: 1661-6596, DOI: 10.3390/ijms222413516
MINDUR JOHN E., SWIRSKI FILIP K.: "Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 39, no. 7, 1 July 2019 (2019-07-01), pages 1275 - 1287, XP093130601, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.119.311994
DR. AXE: "Beef Gelatin: What Are the Benefits & How Does It Compare to Collagen?", DRAXE.COM, DRAXE.COM, 22 February 2021 (2021-02-22), pages 1 - 7, XP093130608, Retrieved from the Internet
Attorney, Agent or Firm:
CUTCHINS, William W. et al. (US)
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