Title:
THIOCHROMAN DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/078488
Kind Code:
A1
Abstract:
Disclosed in the present invention are a thiochroman derivative and a preparation method therefor and a use thereof. The structure of the thiochroman derivative is as shown in general formula (I), and the definition of each substituent is as described in the description and the claims. The thiochroman derivative of the present invention is used as a selective estrogen receptor degrader and antagonist for treating estrogen receptor positive diseases.
Inventors:
YANG YUSHE (CN)
ZHANG DAN (CN)
LU ZHENGYU (CN)
ZHANG DAN (CN)
LU ZHENGYU (CN)
Application Number:
PCT/CN2023/123758
Publication Date:
April 18, 2024
Filing Date:
October 10, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D409/12; A61K31/397; A61K31/4155; A61K31/4162; A61K31/4433; A61K31/453; A61K31/69; A61P3/04; A61P9/00; A61P15/00; A61P19/10; A61P25/00; A61P35/00; A61P35/02; A61P37/02; C07D405/14; C07D495/04
Domestic Patent References:
| WO2012084711A1 | 2012-06-28 | |||
| WO2019228443A1 | 2019-12-05 | |||
| WO2016202161A1 | 2016-12-22 |
Foreign References:
| CN108349952A | 2018-07-31 | |||
| CN1839125A | 2006-09-27 | |||
| CN101106999A | 2008-01-16 | |||
| CN112105607A | 2020-12-18 | |||
| CN1312803A | 2001-09-12 | |||
| EP1229036A1 | 2002-08-07 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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