Title:
THIOCOLCHICINE AND COLCHICINE ANALOGS, METHODS OF MAKING AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/091114
Kind Code:
A3
Abstract:
Disclosed herein are thiocolchicine and colchicine analogs and derivatives suitable for use as a muscle relaxant, an anti-inflammatory agent, an anti-gout agent, an anti-proliferative agent, or an anti-cancer agent; methods of making the compounds, and compositions comprising the compounds.
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Inventors:
NIELSEN KURT R (US)
MANCHANDA RAJESH (US)
WATSON SHAWN G (US)
MANCHANDA RAJESH (US)
WATSON SHAWN G (US)
Application Number:
PCT/US2011/021826
Publication Date:
November 10, 2011
Filing Date:
January 20, 2011
Export Citation:
Assignee:
MUTUAL PHARMACEUTICAL CO (US)
NIELSEN KURT R (US)
MANCHANDA RAJESH (US)
SUN TONG (US)
WATSON SHAWN G (US)
NIELSEN KURT R (US)
MANCHANDA RAJESH (US)
SUN TONG (US)
WATSON SHAWN G (US)
International Classes:
C07C391/00
Other References:
PASSARELLA D ET AL: "Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 16, no. 11, 1 June 2008 (2008-06-01), pages 6269 - 6285, XP022700357, ISSN: 0968-0896, [retrieved on 20080528], DOI: DOI:10.1016/J.BMC.2008.04.025
TRELLU, FILALI-ANSARY, FRANÇON, ADAM, LLUEL, DUBRUCK, THÉNOT: "New metabolic and pharmacokinetic characteristics of thiocolchicoside and its active metabolite in healthy humans", FUNDAMENTAL AND CLINICAL PHARMACOLOGY, vol. 18, 2004, pages 493 - 501, XP002638435
LEYNADIER D ET AL: "Selenium: Inhibition of microtubule formation and interaction with tubulin", CHEMICO-BIOLOGICAL INTERACTIONS, ELSEVIER SCIENCE IRLAND, IR, vol. 79, no. 1, 1 January 1991 (1991-01-01), pages 91 - 102, XP023831395, ISSN: 0009-2797, [retrieved on 19910101], DOI: DOI:10.1016/0009-2797(91)90055-C
TRELLU, FILALI-ANSARY, FRANÇON, ADAM, LLUEL, DUBRUCK, THÉNOT: "New metabolic and pharmacokinetic characteristics of thiocolchicoside and its active metabolite in healthy humans", FUNDAMENTAL AND CLINICAL PHARMACOLOGY, vol. 18, 2004, pages 493 - 501, XP002638435
LEYNADIER D ET AL: "Selenium: Inhibition of microtubule formation and interaction with tubulin", CHEMICO-BIOLOGICAL INTERACTIONS, ELSEVIER SCIENCE IRLAND, IR, vol. 79, no. 1, 1 January 1991 (1991-01-01), pages 91 - 102, XP023831395, ISSN: 0009-2797, [retrieved on 19910101], DOI: DOI:10.1016/0009-2797(91)90055-C
Attorney, Agent or Firm:
PELLETIER, Roberta, L. (20 Church Street22nd Floo, Hartford Connecticut, US)
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