TOLERANCE TO GRAFT FOLLOWING THYMIC REACTIVATION

Title:

TOLERANCE TO GRAFT FOLLOWING THYMIC REACTIVATION

Document Type and Number:

WIPO Patent Application WO2004094649

Kind Code:

A3

Abstract:

The present disclosure provides methods for inducing tolerance in a recipient to a mismatched graft of an organ, tissue, and/or cells, by disrupting sex steroid mediated signaling and reactivating the patient's thymus. In some embodiments, the patient's thymus is reactivated by interruption or ablation of sex steroid mediated signaling by the administration of LHRH agonists, LHRH antagonists, ant-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMs), selective androgen receptor modulators (SARMs), selective progesterone response modulators (SPRMs), ERDs, aromatose inhibitors, or various combinations thereof.

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Inventors:

BOYD RICHARD (AU)

Application Number:

PCT/US2004/011920

Publication Date:

December 01, 2005

Filing Date:

April 19, 2004

Export Citation:

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Assignee:

NORWOOD IMMUNOLOGY LTD (AU)
BOYD RICHARD (AU)

International Classes:

A61K35/14; A61K35/26; A61K35/28; A61K35/36; A61K38/00; A61K38/18; A61K39/00; A61K39/38; A61K39/395; A61K48/00; A61M5/00; A61P37/00; C12N5/00; C12N5/08; C12P21/02; F22B7/04; C12Q; G01N; (IPC1-7): A61K39/00; A61K35/26; A61K35/28; A61K39/38; F22B7/04

Domestic Patent References:

WO2000062657A2	2000-10-26
WO2002031110A2	2002-04-18

Other References: