Title:
TRANSDUCTION OF DENDRITIC CELLS USING ADENOVIRAL VECTORS
Document Type and Number:
WIPO Patent Application WO2002024730
Kind Code:
A3
Abstract:
Adenoviral vectors can be used in vaccines to cause antigen-presenting cells to display desired antigens. Disclosed is a vector and associated means and methods which transduce antigen-presenting cells better than currently available vectors, enabling the vector to be delivered in lower doses, and thus improving the efficiency of adenoviral vaccines technology.
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Inventors:
HAVENGA MENZO (NL)
VOGELS RONALD (NL)
BOUT ABRAHAM (NL)
VOGELS RONALD (NL)
BOUT ABRAHAM (NL)
Application Number:
PCT/EP2001/010999
Publication Date:
June 27, 2002
Filing Date:
September 20, 2001
Export Citation:
Assignee:
CRUCELL HOLLAND BV (NL)
HAVENGA MENZO (NL)
VOGELS RONALD (NL)
BOUT ABRAHAM (NL)
HAVENGA MENZO (NL)
VOGELS RONALD (NL)
BOUT ABRAHAM (NL)
International Classes:
C12N5/08; C12N15/861; A61K48/00; (IPC1-7): C12N15/861; A61K48/00
Domestic Patent References:
| WO1999047180A1 | 1999-09-23 | |||
| WO1998050053A1 | 1998-11-12 | |||
| WO2000031285A1 | 2000-06-02 | |||
| WO2000052186A1 | 2000-09-08 | |||
| WO2000070071A1 | 2000-11-23 |
Other References:
SHAYAKHMETOV D M ET AL: "EFFICIENT GENE TRANSFER INTO HUMAN CD34+ CELLS BY A RETARGETED ADENOVIRUS VECTOR", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 6, March 2000 (2000-03-01), pages 2567 - 2583, XP000938716, ISSN: 0022-538X
REA D ET AL: "Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells.", JOURNAL OF IMMUNOLOGY, (2001 APR 15) 166 (8) 5236-44., - 15 April 2001 (2001-04-15), XP002192775
SEGERMAN A ET AL: "Adenovirus types 11p and 35p show high binding efficiencies for committed hematopoietic cell lines and are infective to these cell lines", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 3, February 2000 (2000-02-01), pages 1457 - 1467, XP002161682, ISSN: 0022-538X
KRASNYKH V N ET AL: "GENERATION OF RECOMBINANT ADENOVIRUS VECTORS WITH MODIFIED FIBERS FOR ALTERING VIRAL TROPISM", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 70, no. 10, 1 October 1996 (1996-10-01), pages 6839 - 6846, XP002067518, ISSN: 0022-538X
ZHONG L ET AL: "RECOMBINANT ADENOVIRUS IS AN EFFICIENT AND NON-PERTUBING GENETIC VECTOR FOR HUMAN DENDRITIC CELLS", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 29, no. 3, 1999, pages 964 - 972, XP000938797, ISSN: 0014-2980
REA D ET AL: "Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells.", JOURNAL OF IMMUNOLOGY, (2001 APR 15) 166 (8) 5236-44., - 15 April 2001 (2001-04-15), XP002192775
SEGERMAN A ET AL: "Adenovirus types 11p and 35p show high binding efficiencies for committed hematopoietic cell lines and are infective to these cell lines", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 3, February 2000 (2000-02-01), pages 1457 - 1467, XP002161682, ISSN: 0022-538X
KRASNYKH V N ET AL: "GENERATION OF RECOMBINANT ADENOVIRUS VECTORS WITH MODIFIED FIBERS FOR ALTERING VIRAL TROPISM", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 70, no. 10, 1 October 1996 (1996-10-01), pages 6839 - 6846, XP002067518, ISSN: 0022-538X
ZHONG L ET AL: "RECOMBINANT ADENOVIRUS IS AN EFFICIENT AND NON-PERTUBING GENETIC VECTOR FOR HUMAN DENDRITIC CELLS", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 29, no. 3, 1999, pages 964 - 972, XP000938797, ISSN: 0014-2980
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