Title:
TRANSGENIC RODENT EXPRESSING TRUNCATED DISC1
Document Type and Number:
WIPO Patent Application WO/2010/007372
Kind Code:
A8
Abstract:
The invention provides transgenic rodents, particularly mice, expressing truncated versions of the Disrupted-in-Schizophrenia-1 (DISC1) gene and showing Schizophrenia- related neural and behavioral phenotypes. The rodents of the invention have (1) a plurality of copies of a heterologous truncated Disc1 genomic DNA sequence which includes at least 1 stop codon after exon 8 such as to encode a Disc1 polypeptide truncated before exon 9; (2) 2 copies of endogenous Disc1 genomic DNA sequence encoding full length Disc1 polypeptide. Also provided are related materials and methods.
Inventors:
SHEN SANBING (GB)
RIEDEL GERNOT (GB)
ST CLAIR DAVID (GB)
RIEDEL GERNOT (GB)
ST CLAIR DAVID (GB)
Application Number:
PCT/GB2009/001757
Publication Date:
February 24, 2011
Filing Date:
July 16, 2009
Export Citation:
Assignee:
UNIV ABERDEEN (GB)
TMRI LTD (GB)
WYETH PHARMACEUTICALS INC (US)
SHEN SANBING (GB)
RIEDEL GERNOT (GB)
ST CLAIR DAVID (GB)
TMRI LTD (GB)
WYETH PHARMACEUTICALS INC (US)
SHEN SANBING (GB)
RIEDEL GERNOT (GB)
ST CLAIR DAVID (GB)
International Classes:
C12N15/85; A01K67/027; C07K14/47; C12N5/07
Attorney, Agent or Firm:
MEWBURN ELLIS LLP (London EC2V 8AS, GB)
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