Title:
TREATMENT OF ADVANCED DECOMPENSATED HEART FAILURE WITH NITRIC OXIDE DONORS
Document Type and Number:
WIPO Patent Application WO1999055317
Kind Code:
A3
Abstract:
Nitric oxide donor compounds which are positive inotropes can be used to treat severe advanced decompensated heart failure in patients, by nitrosylating the L-type calcium channel or the ryanodine receptor so as to increase myocardial contractility. Measuring nitrosylation of either the L-type calcium channel or the ryanodine receptor by a test compound can also be used to screen for candidate positive inotropic drugs.
Inventors:
HARE JOSHUA M
Application Number:
PCT/US1999/009330
Publication Date:
January 27, 2000
Filing Date:
April 30, 1999
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
International Classes:
A61K31/00; (IPC1-7): A61K31/535; A61K33/00; G01N33/483
Other References:
HIMBERT ET AL.: "Acute hemodynamic effects of SIN-1 vs. Isosorbide dinitrate: a double blind, crossover study in stable chronic left ventricular failure", J. CARDIOVASCULAR PHARMACOLOGY, vol. 17, no. Suppl.3, 1991, pages S279 - S286, XP002110615
IBRAHIM ET AL.: "Hemodynamic effects of SIN-1 in acute left heart failure", CARDIOVASCULAR DRUGS AND THERAPY, vol. 3, no. 4, 1989, pages 557 - 561, XP002110616
MOHAN ET AL.: "Myocardial contractile response to nitric oxide and cGMP", CIRCULATION, vol. 93, no. 6, 15 March 1996 (1996-03-15), pages 1223 - 1229, XP002110617
MOORE K P ET AL: "Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite.", CIRCULATION RESEARCH, (1995 AUG) 77 (2) 335-41., XP002110618
IBRAHIM ET AL.: "Hemodynamic effects of SIN-1 in acute left heart failure", CARDIOVASCULAR DRUGS AND THERAPY, vol. 3, no. 4, 1989, pages 557 - 561, XP002110616
MOHAN ET AL.: "Myocardial contractile response to nitric oxide and cGMP", CIRCULATION, vol. 93, no. 6, 15 March 1996 (1996-03-15), pages 1223 - 1229, XP002110617
MOORE K P ET AL: "Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite.", CIRCULATION RESEARCH, (1995 AUG) 77 (2) 335-41., XP002110618
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