Title:
TREATMENT FOR HEMORRHAGIC DISEASES BY ANTI-PROTEIN-C ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2015/041310
Kind Code:
A1
Abstract:
The present inventors have found that an excellent anti-hemocoagulation inhibition effect can be obtained by administering a protein-C activation inhibiting substance, and have thus completed the present invention.
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Inventors:
KITAZAWA TAKEHISA (JP)
NAKANE AYA (JP)
YOSHIHASHI KAZUTAKA (JP)
SOEDA TETSUHIRO (JP)
MUTO ATSUSHI (JP)
NAKANE AYA (JP)
YOSHIHASHI KAZUTAKA (JP)
SOEDA TETSUHIRO (JP)
MUTO ATSUSHI (JP)
Application Number:
PCT/JP2014/074789
Publication Date:
March 26, 2015
Filing Date:
September 19, 2014
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K39/395; A61K45/00; A61P7/04; C07K16/18
Domestic Patent References:
| WO1993009804A1 | 1993-05-27 | |||
| WO2004009641A1 | 2004-01-29 | |||
| WO1994011523A2 | 1994-05-26 | |||
| WO1996002576A1 | 1996-02-01 | |||
| WO1993012227A1 | 1993-06-24 | |||
| WO1992003918A1 | 1992-03-19 | |||
| WO1994002602A1 | 1994-02-03 | |||
| WO1994025585A1 | 1994-11-10 | |||
| WO1996034096A1 | 1996-10-31 | |||
| WO1996033735A1 | 1996-10-31 | |||
| WO1992001047A1 | 1992-01-23 | |||
| WO1992020791A1 | 1992-11-26 | |||
| WO1993006213A1 | 1993-04-01 | |||
| WO1993011236A1 | 1993-06-10 | |||
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| EP0058481A1 | 1982-08-25 | |||
| EP0133988A2 | 1985-03-13 |
Other References:
MESTERS, R. M. ET AL.: "Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 36, 1991, pages 24514 - 24519, XP055328931
SUZUKI, K. ET AL.: "Monoclonal Antibodies to Human Protein C : Effects on the Biological Activity of Activated Protein C and the Thrombin-Catalyzed Activation of Protein C", JOURNAL OF BIOCHEMISTRY, vol. 97, no. 1, 1985, pages 127 - 138, XP008091703
ASTERMARK J., HAEMOPHILIA, vol. 9, no. 1, 2003, pages 32
CASTELLINO FJ; PLOPLIS VA, J THROMB AND HAEMOST, vol. 7, no. 1, 2009, pages 140
VAN DIJK K ET AL., J THROMB AND HAEMOST, vol. 92, 2004, pages 305
SCHLACHTERMAN A ET AL., J THROMB HAEMOST, vol. 3, 2005, pages 2730
BUTENAS S ET AL., J THROMB HAEMOST, vol. 4, 2006, pages 2411
SAMBROOK, J. ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS, pages: 9.47 - 9.58
J. IMMUNOL., vol. 123, no. 4, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
C. EUR. J. IMMUNOL., vol. 6, no. 7, 1976, pages 511 - 519
CELL, vol. 8, no. 3, 1976, pages 405 - 415
NATURE, vol. 276, no. 5685, 1978, pages 269 - 270
J. IMMUNOL. METHODS, vol. 35, no. 1-2, 1980, pages 1 - 21
J. EXP. MED., vol. 148, no. 1, 1978, pages 313 - 323
NATURE, vol. 277, no. 5692, 1979, pages 131 - 133
KOHLER; MILSTEIN ET AL., METHODS ENZYMOL, vol. 73, 1981, pages 3 - 46
VANDAMME ET AL., EUR. J. BIOCHEM., vol. 192, no. 3, 1990, pages 767 - 775
BIOCHEMISTRY, vol. 18, no. 24, 1979, pages 5294 - 5299
ANAL. BIOCHEM., vol. 162, no. 1, 1987, pages 156 - 159
PROC. NATL. ACAD. SCI. USA, vol. 85, no. 23, 1988, pages 8998 - 9002
NUCLEIC ACIDS RES., vol. 17, no. 8, 1989, pages 2919 - 2932
BIO/TECHNOLOGY, vol. 12, no. 7, 1994, pages 699 - 702
CANCER RES., vol. 53, 1993, pages 851 - 856
BERNASCONI ET AL., SCIENCE, vol. 298, 2002, pages 2199 - 2202
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
"Remington's Pharmaceutical Science", 1980
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 267 - 277
LANGER, CHEMTECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
OKUDA, M.; YAMAMOTO, Y., CLIN. LAB. HAEM., vol. 26, 2004, pages 215 - 223
See also references of EP 3047857A4
SUZUKI, K. ET AL.: "Monoclonal Antibodies to Human Protein C : Effects on the Biological Activity of Activated Protein C and the Thrombin-Catalyzed Activation of Protein C", JOURNAL OF BIOCHEMISTRY, vol. 97, no. 1, 1985, pages 127 - 138, XP008091703
ASTERMARK J., HAEMOPHILIA, vol. 9, no. 1, 2003, pages 32
CASTELLINO FJ; PLOPLIS VA, J THROMB AND HAEMOST, vol. 7, no. 1, 2009, pages 140
VAN DIJK K ET AL., J THROMB AND HAEMOST, vol. 92, 2004, pages 305
SCHLACHTERMAN A ET AL., J THROMB HAEMOST, vol. 3, 2005, pages 2730
BUTENAS S ET AL., J THROMB HAEMOST, vol. 4, 2006, pages 2411
SAMBROOK, J. ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS, pages: 9.47 - 9.58
J. IMMUNOL., vol. 123, no. 4, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
C. EUR. J. IMMUNOL., vol. 6, no. 7, 1976, pages 511 - 519
CELL, vol. 8, no. 3, 1976, pages 405 - 415
NATURE, vol. 276, no. 5685, 1978, pages 269 - 270
J. IMMUNOL. METHODS, vol. 35, no. 1-2, 1980, pages 1 - 21
J. EXP. MED., vol. 148, no. 1, 1978, pages 313 - 323
NATURE, vol. 277, no. 5692, 1979, pages 131 - 133
KOHLER; MILSTEIN ET AL., METHODS ENZYMOL, vol. 73, 1981, pages 3 - 46
VANDAMME ET AL., EUR. J. BIOCHEM., vol. 192, no. 3, 1990, pages 767 - 775
BIOCHEMISTRY, vol. 18, no. 24, 1979, pages 5294 - 5299
ANAL. BIOCHEM., vol. 162, no. 1, 1987, pages 156 - 159
PROC. NATL. ACAD. SCI. USA, vol. 85, no. 23, 1988, pages 8998 - 9002
NUCLEIC ACIDS RES., vol. 17, no. 8, 1989, pages 2919 - 2932
BIO/TECHNOLOGY, vol. 12, no. 7, 1994, pages 699 - 702
CANCER RES., vol. 53, 1993, pages 851 - 856
BERNASCONI ET AL., SCIENCE, vol. 298, 2002, pages 2199 - 2202
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
"Remington's Pharmaceutical Science", 1980
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 267 - 277
LANGER, CHEMTECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
OKUDA, M.; YAMAMOTO, Y., CLIN. LAB. HAEM., vol. 26, 2004, pages 215 - 223
See also references of EP 3047857A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Masao Haruna (JP)
Masao Haruna (JP)
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