Title:
TRIARYLCARBOXYLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/043457
Kind Code:
A1
Abstract:
It is intended to provide a remedy or a preventive for hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinitis and so on which has a non-nucleic acid structure and exerts an excellent xanthine oxidase inhibitory effect and a uric acid level-lowering effect. It has been confirmed that a novel triarylcarboxlic acid derivative, which is characterized by having a carboxyl-substituted heteroaryl group and an aromatic ring group such as a phenyl group attached in para-position on a benzene ring and further carrying a cyano group on the same benzene ring, has a potent xanthine oxidase inhibitory effect and a uric acid level-lowering effect. Thus, it is found out that this compound is appropriately usable as a remedy or a preventive for hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinitis and so on.
Inventors:
SATO JUNJI (JP)
HATTORI KAZUYUKI (JP)
KUBOTA HIROKAZU (JP)
MUNAKATA RYOSUKE (JP)
ASANO TORU (JP)
WATANABE JUNKO (JP)
KAWAKAMI MASAKATSU (JP)
KAMIKAWA AKIO (JP)
HATTORI KAZUYUKI (JP)
KUBOTA HIROKAZU (JP)
MUNAKATA RYOSUKE (JP)
ASANO TORU (JP)
WATANABE JUNKO (JP)
KAWAKAMI MASAKATSU (JP)
KAMIKAWA AKIO (JP)
Application Number:
PCT/JP2006/320061
Publication Date:
April 19, 2007
Filing Date:
October 06, 2006
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
SATO JUNJI (JP)
HATTORI KAZUYUKI (JP)
KUBOTA HIROKAZU (JP)
MUNAKATA RYOSUKE (JP)
ASANO TORU (JP)
WATANABE JUNKO (JP)
KAWAKAMI MASAKATSU (JP)
KAMIKAWA AKIO (JP)
SATO JUNJI (JP)
HATTORI KAZUYUKI (JP)
KUBOTA HIROKAZU (JP)
MUNAKATA RYOSUKE (JP)
ASANO TORU (JP)
WATANABE JUNKO (JP)
KAWAKAMI MASAKATSU (JP)
KAMIKAWA AKIO (JP)
International Classes:
A61K31/381; C07D213/79; A61K31/4025; A61K31/404; A61K31/415; A61K31/4155; A61K31/42; A61K31/425; A61K31/426; A61K31/427; A61K31/4418; A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4535; A61K31/4709; A61K31/4725; A61K31/497; A61K31/506; A61K31/5377; A61K31/55; A61P1/04; A61P19/06; A61P27/00; A61P43/00; C07D231/14; C07D261/18; C07D275/03; C07D277/20; C07D277/56; C07D333/40; C07D333/60; C07D333/76; C07D401/10; C07D405/10; C07D409/10; C07D413/10; C07D417/10
Domestic Patent References:
| WO1992009279A1 | 1992-06-11 | |||
| WO2006022374A1 | 2006-03-02 | |||
| WO2006022375A1 | 2006-03-02 |
Other References:
See also references of EP 1932832A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (Intellectual Property 3-11, Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)
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