TRICYCLIC ANILIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS

Title:

TRICYCLIC ANILIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS

Document Type and Number:

WIPO Patent Application WO2006031491

Kind Code:

A3

Abstract:

The present invention is directed to compounds of Formula I: I (where A¹, A², B¹, B², B³, B⁴, D¹, D², J, K, T, U, V, W, X, Y, Z, R⁴, R^5a, R^5b, R^5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Inventors:

BELL IAN M (US)
GALLICCHIO STEVEN N (US)
STUMP CRAIG A (US)
THEBERGE CORY R (US)
VACCA JOSEPH P (US)
ZARTMAN C BLAIR (US)
ZHANG XUFANG (US)

Application Number:

PCT/US2005/031617

Publication Date:

November 09, 2006

Filing Date:

September 06, 2005

Export Citation:

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Assignee:

MERCK & CO INC (US)
BELL IAN M (US)
GALLICCHIO STEVEN N (US)
STUMP CRAIG A (US)
THEBERGE CORY R (US)
VACCA JOSEPH P (US)
ZARTMAN C BLAIR (US)
ZHANG XUFANG (US)

International Classes:

C07D471/02; A61K31/505

Foreign References:

US6548505B1

2003-04-15

Other References: